Impact of Genomics Research Flashcards
1
Q
Human Genome Project
A
- Human genome consists of 3.1 billion base pairs
- Single nucleotide polymorphisms and copy number variations such as long deletions, insertions, duplications account for much of genome diversity between humans
- 20,000 protein-coding genes
2
Q
Types of ‘omics’
A
3
Q
Structural Genomics
A
Determine the 3D structure of all proteins encoded by a given genome
- Structure but not function
4
Q
Impacts of Structural Genomics
A
5
Q
Were SG projects cost effective?
A
- More effective
- Less expensive
- More likely to succeed
6
Q
What is the proteome?
A
The protein complement encoded by a genome
7
Q
Structural Proteomics
A
- Identifying all the proteins made in a given cell, tissue, or organism
- Determining how these proteins function together to form networks
- solving the precise three-dimensional structures of these proteins in an effort to understand and to effect molecular interactions important for drug discovery
8
Q
Why is Structural Proteomics important?
A
9
Q
Practical considerations for target selection
A
10
Q
Why is moving from structural genomics to structural proteomics crucial for bioinformatics?
A
- Data is easier and cheaper to obtain
- HG project and SG initiatives have contributed to a vast amount of data, at an alarming rate
- Not feasible to solve ALL proteins in ALL species, therefore, bioinformatics (in silico) approaches are very important - AlphaFold
11
Q
Why is bioinformatics crucial?
A
