Immunoupdates (Lect. 13-15)

Question 1

What is the effect of T cell depleting diseases on the Thymic Shadow seen on X-ray?

Answer 1

• Thymic Shadow will not show up for any disease where there are no T cells (not just DiGeorge)

Question 2

How does HIV cause T cell Loss?

Answer 2

CD8 T-cells become activated to kill CD4 T-cells infected with HIV

Question 3

How long after the infection does it take for CD8 T-cells to recognized HIV infected CD4 cells?

Answer 3

2-6 weeks usually

• At this time patients may experience Flu-Like Symptoms

Question 4

T or F: patients with DiGeorge Syndrome will have Ig in their blood

Answer 4

True, the patients have B cells - they just won’t be able to proliferate or class switch from IgM

Question 5

What is the Clinical Triad associated with Wiskott Aldrich Syndrome?

Answer 5

1. THROMBOCYTOPENIA
2. ECZEMA
3. RECURRENT INFECTIONS

Question 6

What are the B cell markers?

Answer 6

CD19
CD20
CD21

Question 7

T or F: patients with neutropenia are prone to Hematologic Dissemination.

Answer 7

True, if they lack neutrophils, it will be hard for them to beat an infection back and it can spread through the blood