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Body Systems Pharmacology > Immunosupressors > Flashcards

Immunosupressors Flashcards

1
Q

Calcineurin inhibitor that binds to FK506

A

Tacrolimus

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2
Q

> potent Calcinuerin inhibitor

A

Tacrolimus

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3
Q

MOA of Calcineurin inhibitors

A

inhibition of NFAT activation → ↓IL-2

Inhibits phosphatase activity

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4
Q

Main side effect of Calcineurin inhibitors

A

Nephrotoxicity

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5
Q

Calcinuerin inhibitor that can cause CNS side effects

A

Tacrolimus

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6
Q

Calcinuerin inhibitor that causes:
hyperlipidemia
hyperuricemia
hyperglicemia

A

Cyclosporine

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7
Q

Gum hyperplasia

A

Cyclosporine

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8
Q

Calcinuerin inhibitor related to hyperkalemia as side effect

A

Tacrolimus

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9
Q

Contraindications of Calcinuerin inhibitors

A

Diabetes
CYPA4 inhibitors or inducers

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10
Q

These two immunosuppressors have a synergistic effect, and can cause:
- ↑ Renal dysfunction of cylosporine
- ↑ Hyperlipidemia and myelosupression

A

Cyclosporin + Sirolimus

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11
Q

T or F: Antiarrythmics have an interaction with Calcineurin inhibitors

A

T

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12
Q

mTOR inhibitor

A

Sirolimus

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13
Q

Binds to FKBP

A

Sirolimus

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14
Q

Cyclosporine binds to….

A

Cyclophilin

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15
Q

Used to coat stents

A

Sirolimus

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16
Q

T or F: Sirolimus is Nephrotoxic

A

F

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17
Q

Immunomodulator that causes insulin resistance

A

Sirolimus

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18
Q

Adverse Effects of Sirolimus

A

Pancytopenia
Insulin resistance
Hyperlipidemia
Mouth ulcer

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19
Q

Antimetabolites: Purine Ana

A
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20
Q

Purine Analogue

A

Azathioprine

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21
Q

Antimetabolite used to tx Leukemias

A

Azathioprine

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22
Q

Coadmin with Allopurinol causes toxic accumulation of this drug

A

Azathioprine

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23
Q

Common side effect of antimetabolites

A

Bone Marrow suppression

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24
Q

Antimetabolite that can cause liver toxicity (cholestasis)

A

Azathioprine

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25
Q

T or F: Azathioprine, Mycophenolate Moefetil and Methotrexate are CONTRAINDICATED @Pregnancy

A

T

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26
Q

Prophylaxis vs Kidney transplant

A

Sirolimus

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27
Q

Side effect: infection by CMV

A

Mycophenolate Moefetil

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28
Q

Folic acid antagonist/analogue

A

Methotrexate

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29
Q

Inhibition of DHFR

A

Methotrexate

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30
Q

Reversible inhibition of IMDH

A

Mycophenolate Moefetil

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31
Q

Antimetabolite that can be administered Intrathecally

A

Methotrexate

32
Q

Medical abortion

A

Methotrexate

33
Q

immunosuppressant that can cause Pulmonary Fibrosis

A

Methotrexate

34
Q

Leukovorin rescue

A

@Methotrxate overdose
Is a reduced form of folic acid
Displaces Methotrexate from binding site

35
Q

Intermediate acting Glucocorticoids

A

Predinosone
Predisolone
Methilpredisolone

36
Q

Glucocorticoid that acts for 12-36 hrs

A

Intermediate:
Predinosone
Prednisolone
Methilprednisolone

37
Q

T or F = Dexamethasone is 25x > potent than short acting

A

T

38
Q

Glucocorticoid for speed up lung maturation @fetus during pregnancy

A

Bethamethasone (long acting)

39
Q

How long does Long Acting Glucocorticoids last?

A

36-72 hrs

40
Q

Inhibition of NF-kB → suppression of B and T cells

A

Glucocorticoids

41
Q

T or F: Long term effect (hours) have a direct influence on gene expression → ↑ Tcell apoptosis
@Glucorticoids

A

T

42
Q

Type of glucocorticoid for Atopy and asthma tx

A

Intermediate

43
Q

Adrenal Insufficiency is Tx with _____ acting Glucocorticoids

A

Short

44
Q

Immunosuppressor used to relief cerebral edema in brain tumors

A

Dexamethasone

45
Q

Overnight Dexathasone Suppression Test

A

Cushing

46
Q

Intermediate acting Glucocorticoid with TOPICAL admin

A

Predinisolone

47
Q

Intermediate acting Glucocorticoid with IV, IM and Intraarticular admin

A

Methylpredinosolone

48
Q

Glucocorticoid used in px with liver disease or not able to swallow pills

A

Prednisolone
bc of peroral admin

49
Q

Abrupt discontinuation of Glucocorticoids cuases

A

Flare-up of underling disease

50
Q

Can cause diminished growth @children

A

Glucocorticoids

51
Q

Peptic ulcers

A

Glucocorticoids

52
Q

Contraindications of Glucocorticoids

A

Fungal infections
Live vaccines
Premature infants
Cushing
Diabetes
Osteoporosis
Peptic ulcers

53
Q

Causes “demmargination” of Neutrophils, causing ↑Neutrophils @blood

A

Glucocorticoids

54
Q

Chimeric Monoclonal antibodies

A

Infliximab
Rituximab

55
Q

Anti-CD20 monoclonal antibody

A

Rituximab

56
Q

Monoclonal antibodies that bind to TNFa

A

Infliximab
Adalimumab

57
Q

Needs screening for TB

A

Infliximab
Adalimumab

58
Q

Monoclonal antibodies used to tx IBD

A

Infliximab
Adalimumab
= Anti-TNFa

59
Q

Contraindications in Monoclonal antibodies

A

Congestive heart failure
Active infections

60
Q

Must be screened for HBV before starting tx

A

Rituximab

61
Q

Monoclonal antibody used to tx Multiple Sclerosis

A

Rituximab

62
Q

T or F: Monoclonal antibody anti-TNFa are indicated for MS tx

A

F
Its contraindicated

63
Q

Lupus like syndrome

A

Infliximab
Adalimumab

64
Q

Acts as decoy for T cells instead of attacking neural myelin

A

Glatiramer

65
Q

Lipoatrophy

A

Glatiramer

66
Q

Best safety profile for pregnant women with mild Multiple Sclerosis disease

A

Glatiramer

67
Q

Glatiramer is a…

A

synthetic polypeptide

68
Q

Used for enzyme replacement therapy

A

Elapegmedasa

69
Q

Acts as exogenous adenosine deaminase (ADA)

A

Elpegmedasa

70
Q

Used to tx Sevre combined immunodeficiencies

A

Elapegmedasa

71
Q

CDK4/6 inhibitor

A

Trilaciclib

72
Q

Immunomodulator that slows down cell cycle by ↓ proliferation of cancer cells

A

Trilaciclib

73
Q

Chemotherapy induced myelosuppresion @Px with extensive-stage cell lung cancer

A

Trilaciclib

74
Q

Injection site reactions: Phlebitis, Thrombophlebitis

A

Trilaciclib

75
Q

T or F: Trilaciclib is safe during pregnancy

A

F

76
Q

Hematopoietic Stem Cell Mobilizer

A

Plerixaflor

77
Q

Blocks binding of CXC12 to CXC4

A

Plerixaflor

Body Systems Pharmacology (6 decks)

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