Immunosupressors

Question 1

Calcineurin inhibitor that binds to FK506

Answer 1

Tacrolimus

Question 2

> potent Calcinuerin inhibitor

Answer 2

Tacrolimus

Question 3

MOA of Calcineurin inhibitors

Answer 3

inhibition of NFAT activation → ↓IL-2

Inhibits phosphatase activity

Question 4

Main side effect of Calcineurin inhibitors

Answer 4

Nephrotoxicity

Question 5

Calcinuerin inhibitor that can cause CNS side effects

Answer 5

Tacrolimus

Question 6

Calcinuerin inhibitor that causes:
hyperlipidemia
hyperuricemia
hyperglicemia

Answer 6

Cyclosporine

Question 7

Gum hyperplasia

Answer 7

Cyclosporine

Question 8

Calcinuerin inhibitor related to hyperkalemia as side effect

Answer 8

Tacrolimus

Question 9

Contraindications of Calcinuerin inhibitors

Answer 9

Diabetes
CYPA4 inhibitors or inducers

Question 10

These two immunosuppressors have a synergistic effect, and can cause:
- ↑ Renal dysfunction of cylosporine
- ↑ Hyperlipidemia and myelosupression

Answer 10

Cyclosporin + Sirolimus

Question 11

T or F: Antiarrythmics have an interaction with Calcineurin inhibitors

Answer 11

T

Question 12

mTOR inhibitor

Answer 12

Sirolimus

Question 13

Binds to FKBP

Answer 13

Sirolimus

Question 14

Cyclosporine binds to….

Answer 14

Cyclophilin

Question 15

Used to coat stents

Answer 15

Sirolimus

Question 16

T or F: Sirolimus is Nephrotoxic

Answer 16

F

Question 17

Immunomodulator that causes insulin resistance

Answer 17

Sirolimus

Question 18

Adverse Effects of Sirolimus

Answer 18

Pancytopenia
Insulin resistance
Hyperlipidemia
Mouth ulcer

Question 19

Antimetabolites: Purine Ana

Question 20

Purine Analogue

Answer 20

Azathioprine

Question 21

Antimetabolite used to tx Leukemias

Answer 21

Azathioprine

Question 22

Coadmin with Allopurinol causes toxic accumulation of this drug

Answer 22

Azathioprine

Question 23

Common side effect of antimetabolites

Answer 23

Bone Marrow suppression

Question 24

Antimetabolite that can cause liver toxicity (cholestasis)

Answer 24

Azathioprine

Question 25

T or F: Azathioprine, Mycophenolate Moefetil and Methotrexate are CONTRAINDICATED @Pregnancy

Answer 25

T

Question 26

Prophylaxis vs Kidney transplant

Answer 26

Sirolimus

Question 27

Side effect: infection by CMV

Answer 27

Mycophenolate Moefetil

Question 28

Folic acid antagonist/analogue

Answer 28

Methotrexate

Question 29

Inhibition of DHFR

Answer 29

Methotrexate

Question 30

Reversible inhibition of IMDH

Answer 30

Mycophenolate Moefetil

Question 31

Antimetabolite that can be administered Intrathecally

Answer 31

Methotrexate

Question 32

Medical abortion

Answer 32

Methotrexate

Question 33

immunosuppressant that can cause Pulmonary Fibrosis

Answer 33

Methotrexate

Question 34

Leukovorin rescue

Answer 34

@Methotrxate overdose Is a reduced form of folic acid Displaces Methotrexate from binding site

Question 35

Intermediate acting Glucocorticoids

Answer 35

Predinosone Predisolone Methilpredisolone

Question 36

Glucocorticoid that acts for 12-36 hrs

Answer 36

Intermediate: Predinosone Prednisolone Methilprednisolone

Question 37

T or F = Dexamethasone is 25x > potent than short acting

Answer 37

T

Question 38

Glucocorticoid for speed up lung maturation @fetus during pregnancy

Answer 38

Bethamethasone (long acting)

Question 39

How long does Long Acting Glucocorticoids last?

Answer 39

36-72 hrs

Question 40

Inhibition of NF-kB → suppression of B and T cells

Answer 40

Glucocorticoids

Question 41

T or F: Long term effect (hours) have a direct influence on gene expression → ↑ Tcell apoptosis @Glucorticoids

Answer 41

T

Question 42

Type of glucocorticoid for Atopy and asthma tx

Answer 42

Intermediate

Question 43

Adrenal Insufficiency is Tx with _____ acting Glucocorticoids

Answer 43

Short

Question 44

Immunosuppressor used to relief cerebral edema in brain tumors

Answer 44

Dexamethasone

Question 45

Overnight Dexathasone Suppression Test

Answer 45

Cushing

Question 46

Intermediate acting Glucocorticoid with TOPICAL admin

Answer 46

Predinisolone

Question 47

Intermediate acting Glucocorticoid with IV, IM and Intraarticular admin

Answer 47

Methylpredinosolone

Question 48

Glucocorticoid used in px with liver disease or not able to swallow pills

Answer 48

Prednisolone bc of peroral admin

Question 49

Abrupt discontinuation of Glucocorticoids cuases

Answer 49

Flare-up of underling disease

Question 50

Can cause diminished growth @children

Answer 50

Glucocorticoids

Question 51

Peptic ulcers

Answer 51

Glucocorticoids

Question 52

Contraindications of Glucocorticoids

Answer 52

Fungal infections Live vaccines Premature infants Cushing Diabetes Osteoporosis Peptic ulcers

Question 53

Causes "demmargination" of Neutrophils, causing ↑Neutrophils @blood

Answer 53

Glucocorticoids

Question 54

Chimeric Monoclonal antibodies

Answer 54

Infliximab Rituximab

Question 55

Anti-CD20 monoclonal antibody

Answer 55

Rituximab

Question 56

Monoclonal antibodies that bind to TNFa

Answer 56

Infliximab Adalimumab

Question 57

Needs screening for TB

Answer 57

Infliximab Adalimumab

Question 58

Monoclonal antibodies used to tx IBD

Answer 58

Infliximab Adalimumab = Anti-TNFa

Question 59

Contraindications in Monoclonal antibodies

Answer 59

Congestive heart failure Active infections

Question 60

Must be screened for HBV before starting tx

Answer 60

Rituximab

Question 61

Monoclonal antibody used to tx Multiple Sclerosis

Answer 61

Rituximab

Question 62

T or F: Monoclonal antibody anti-TNFa are indicated for MS tx

Answer 62

F Its contraindicated

Question 63

Lupus like syndrome

Answer 63

Infliximab Adalimumab

Question 64

Acts as decoy for T cells instead of attacking neural myelin

Answer 64

Glatiramer

Question 65

Lipoatrophy

Answer 65

Glatiramer

Question 66

Best safety profile for pregnant women with mild Multiple Sclerosis disease

Answer 66

Glatiramer

Question 67

Glatiramer is a...

Answer 67

synthetic polypeptide

Question 68

Used for enzyme replacement therapy

Answer 68

Elapegmedasa

Question 69

Acts as exogenous adenosine deaminase (ADA)

Answer 69

Elpegmedasa

Question 70

Used to tx Sevre combined immunodeficiencies

Answer 70

Elapegmedasa

Question 71

CDK4/6 inhibitor

Answer 71

Trilaciclib

Question 72

Immunomodulator that slows down cell cycle by ↓ proliferation of cancer cells

Answer 72

Trilaciclib

Question 73

Chemotherapy induced myelosuppresion @Px with extensive-stage cell lung cancer

Answer 73

Trilaciclib

Question 74

Injection site reactions: Phlebitis, Thrombophlebitis

Answer 74

Trilaciclib

Question 75

T or F: Trilaciclib is safe during pregnancy

Answer 75

F

Question 76

Hematopoietic Stem Cell Mobilizer

Answer 76

Plerixaflor

Question 77

Blocks binding of CXC12 to CXC4

Answer 77

Plerixaflor