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Body Systems Pharmacology > Analgesics and NSAIDs > Flashcards

Analgesics and NSAIDs Flashcards

1
Q

Sulindaco

A

Non selective COX inhibitor

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2
Q

Ketoprofen

A

Non selective COX inhibitor

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3
Q

Naproxen

A

Non selective COX inhibitor

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4
Q

Piroxicam

A

Non selective COX inhibitor

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5
Q

Diclofenac

A

Selective COX-2 inhibitor

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6
Q

Colecoxib

A

Selective COX-2 inhibitor

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7
Q

Analgesic used for post-operative cataracts extraction

A

Diclofenac

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8
Q

Pain and Photophobia @Corneal Refractive Surgery

A

Diclofenac

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9
Q

MOST hepatotoxic NSAID

A

Diclofenac

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10
Q

Analgesic MOST associated with Hepatic impairment

A

Diclofenac

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11
Q

Analgesic that can cause CNS side effects

A

Diclofenac
Sulindaco

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12
Q

Analgesic associated with cardiovascular risk

A

Diclofenac
Colecoxib
Ketoprofen

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13
Q

T or F: Methotrexate can cause displacement of NSAIDs form their binding site

A

T

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14
Q

NSAIDs interaction with Lithium

A

↓ renal excretion = toxicity of lithium

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15
Q

Glucocorticoids + NSAIDs

A

↑↑↑ risk of GI complications

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16
Q

NSAIDs + Anticoagulants (ex Warfarin) causes ↑ risk of bleeding…. except for:

A

Ibuprofen
Naproxen

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17
Q

ACE inhibitors + NSAIDs

A

↓ ACE inhibitors effectiveness by blocking the production of vasodilator and natriuretic PGs
Causes Hyperkalemia → Cardiac Arrythmias

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18
Q

NSAID use is contraindicates in the tx of preoperative pain in the setting of…

A

CABG (coronary artery bypass graft) surgery

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19
Q

Px with severe renal/hepatic impairment can use NSAIDs?

A

NO

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20
Q

COX expressed in ALL tissues, specially gastric and renal mucosa

A

COX-1

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21
Q

Aspirin is an IRREVERSIBLE inhibitor of which type of COX?

A

COX-2

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22
Q

NSAID that can be administered in suppositories

A

Naproxen

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23
Q

NSAID slightly more efficient in:
Analgesia
Morning Stiffness

A

Naproxen

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24
Q

Analgesic usually used in Gout

A

Naproxen

25
Q

NSAID used in patent ductus arteriosis

A

Indomethacin

26
Q

Enolic Acid derivative with LESS gastric injury

A

Meloxicam

27
Q

Analgesic used for long-tx of:
Osteoarthritis
RA
Juvenile Arthirits

A

Meloxicam

28
Q

T or F: Meloxicam is a non selective COX inhibitor

A

F: it has SOME selectivity against COX-2

29
Q

Analgesic for px with Peptic Ulcer Disease and Platlet Disorders

A

Colecoxib

30
Q

Side Effect of chronic use of Colecoxib

A

↓ bone mineral density

31
Q

Contraindications of Colecoxib

A

Sulfa drug allergy
severe Heart failure

32
Q

Coelcoxib + Aspirin

A

Colecoxib looses GI advantage over other NSAIDs

33
Q

Analgesic that acts as a peroxide site of enzyme

A

Paracetamol

34
Q

Paracetamol has weak…

A

Anti-inflammatory activity

35
Q

Preferred analgesic/antipyretic drug during Pregnancy

A

Paracetamol

36
Q

Acetaminophen antidote

A

N-acetylsysteine OR
activated charcoal <4hrs after ingestion

37
Q

Toxic metabolite of Paracetamol whose accumulation causes Hepatotoxicity

A

NAPQI

38
Q

Adverse Effects of Paracetamol

A

Nephrotoxicity
Hepatotoxicity

39
Q

Why is Celecoxib is the only approved analgesic of its type

A

Bc of the cardiovascular complications caused by suppression of cardioprotective COX-2 derivative PGI

40
Q

Xanthine Oxidase Inhibitor

A

Allopurinol

41
Q

The inhibition of Xanthine Oxidase causes….

A

Hypoxanthine and Xanthine to NOT be degraded into Uric acid

42
Q

Allopurinol is a ____ inhibitor

A

Competetive

43
Q

First line in Urate-lowering therapy

A

Allopurinol

44
Q

Steven Johnsons Synd.

A

Allopurinol

45
Q

The presence of HLA-B*501 is a contradiction for

A

Allopurinol

46
Q

Allopurinol + Purine Analogs →

A

Bone Marrow Toxicity (accumulation of toxic active metabolites of purine anologs)

47
Q

Principal metabolite of Allopurinol

A

Oxypurinol

48
Q

Chronic Gout

A

Allopurinol

49
Q

Acute Gout

A

Indomithacen

50
Q

Adverse effects of Allopurinol

A

Rash (Maculopapular Exanthema)
Steven Johnsons Stnd

51
Q

Pharmacotherapy for Gout

A

Allopurinol
Colchincine

52
Q

Adverse effect of Colchincine

A

GI symptoms
CNS symptoms
Rhadomyolisis
Cardiac toxicity
Nephrotoxicity

53
Q

Px with Ulcers who need acute gout tx

A

Colchicine
bc the px does not tolerate NSAIDs or Glucocorticoids

54
Q

Muscle Relaxant

A

Methocarbamol

55
Q

T or F: Methocarbamol unlike neuromuscular blocking agents, it dies NOT depress:
Neural condition
Neuromuscular transmission
Muscle excitability

A

T

56
Q

Binds to tubular subunits and inhibits their polymerization → inhibiting phagocytosis

A

Colchincine

57
Q

When should Colchincine tx be started

A

> 24-36hrs AFTER symptom onset

58
Q

NSAIDs used to tx Gout

A

Naproxen
Sulindaco
Celecoxib

59
Q

At what age is NSAID use NOT contraindicated

A

≥12yo

Body Systems Pharmacology (6 decks)

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