Analgesics and NSAIDs

Question 1

Sulindaco

Answer 1

Non selective COX inhibitor

Question 2

Ketoprofen

Answer 2

Non selective COX inhibitor

Question 3

Naproxen

Answer 3

Non selective COX inhibitor

Question 4

Piroxicam

Answer 4

Non selective COX inhibitor

Question 5

Diclofenac

Answer 5

Selective COX-2 inhibitor

Question 6

Colecoxib

Answer 6

Selective COX-2 inhibitor

Question 7

Analgesic used for post-operative cataracts extraction

Answer 7

Diclofenac

Question 8

Pain and Photophobia @Corneal Refractive Surgery

Answer 8

Diclofenac

Question 9

MOST hepatotoxic NSAID

Answer 9

Diclofenac

Question 10

Analgesic MOST associated with Hepatic impairment

Answer 10

Diclofenac

Question 11

Analgesic that can cause CNS side effects

Answer 11

Diclofenac
Sulindaco

Question 12

Analgesic associated with cardiovascular risk

Answer 12

Diclofenac
Colecoxib
Ketoprofen

Question 13

T or F: Methotrexate can cause displacement of NSAIDs form their binding site

Answer 13

T

Question 14

NSAIDs interaction with Lithium

Answer 14

↓ renal excretion = toxicity of lithium

Question 15

Glucocorticoids + NSAIDs

Answer 15

↑↑↑ risk of GI complications

Question 16

NSAIDs + Anticoagulants (ex Warfarin) causes ↑ risk of bleeding…. except for:

Answer 16

Ibuprofen
Naproxen

Question 17

ACE inhibitors + NSAIDs

Answer 17

↓ ACE inhibitors effectiveness by blocking the production of vasodilator and natriuretic PGs
Causes Hyperkalemia → Cardiac Arrythmias

Question 18

NSAID use is contraindicates in the tx of preoperative pain in the setting of…

Answer 18

CABG (coronary artery bypass graft) surgery

Question 19

Px with severe renal/hepatic impairment can use NSAIDs?

Answer 19

NO

Question 20

COX expressed in ALL tissues, specially gastric and renal mucosa

Answer 20

COX-1

Question 21

Aspirin is an IRREVERSIBLE inhibitor of which type of COX?

Answer 21

COX-2

Question 22

NSAID that can be administered in suppositories

Answer 22

Naproxen

Question 23

NSAID slightly more efficient in:
Analgesia
Morning Stiffness

Answer 23

Naproxen

Question 24

Analgesic usually used in Gout

Answer 24

Naproxen

Question 25

NSAID used in patent ductus arteriosis

Answer 25

Indomethacin

Question 26

Enolic Acid derivative with LESS gastric injury

Answer 26

Meloxicam

Question 27

Analgesic used for long-tx of:
Osteoarthritis
RA
Juvenile Arthirits

Answer 27

Meloxicam

Question 28

T or F: Meloxicam is a non selective COX inhibitor

Answer 28

F: it has SOME selectivity against COX-2

Question 29

Analgesic for px with Peptic Ulcer Disease and Platlet Disorders

Answer 29

Colecoxib

Question 30

Side Effect of chronic use of Colecoxib

Answer 30

↓ bone mineral density

Question 31

Contraindications of Colecoxib

Answer 31

Sulfa drug allergy
severe Heart failure

Question 32

Coelcoxib + Aspirin

Answer 32

Colecoxib looses GI advantage over other NSAIDs

Question 33

Analgesic that acts as a peroxide site of enzyme

Answer 33

Paracetamol

Question 34

Paracetamol has weak…

Answer 34

Anti-inflammatory activity

Question 35

Preferred analgesic/antipyretic drug during Pregnancy

Answer 35

Paracetamol

Question 36

Acetaminophen antidote

Answer 36

N-acetylsysteine OR
activated charcoal <4hrs after ingestion

Question 37

Toxic metabolite of Paracetamol whose accumulation causes Hepatotoxicity

Answer 37

NAPQI

Question 38

Adverse Effects of Paracetamol

Answer 38

Nephrotoxicity
Hepatotoxicity

Question 39

Why is Celecoxib is the only approved analgesic of its type

Answer 39

Bc of the cardiovascular complications caused by suppression of cardioprotective COX-2 derivative PGI

Question 40

Xanthine Oxidase Inhibitor

Answer 40

Allopurinol

Question 41

The inhibition of Xanthine Oxidase causes….

Answer 41

Hypoxanthine and Xanthine to NOT be degraded into Uric acid

Question 42

Allopurinol is a ____ inhibitor

Answer 42

Competetive

Question 43

First line in Urate-lowering therapy

Answer 43

Allopurinol

Question 44

Steven Johnsons Synd.

Answer 44

Allopurinol

Question 45

The presence of HLA-B*501 is a contradiction for

Answer 45

Allopurinol

Question 46

Allopurinol + Purine Analogs →

Answer 46

Bone Marrow Toxicity (accumulation of toxic active metabolites of purine anologs)

Question 47

Principal metabolite of Allopurinol

Answer 47

Oxypurinol

Question 48

Chronic Gout

Answer 48

Allopurinol

Question 49

Acute Gout

Answer 49

Indomithacen

Question 50

Adverse effects of Allopurinol

Answer 50

Rash (Maculopapular Exanthema)
Steven Johnsons Stnd

Question 51

Pharmacotherapy for Gout

Answer 51

Allopurinol
Colchincine

Question 52

Adverse effect of Colchincine

Answer 52

GI symptoms
CNS symptoms
Rhadomyolisis
Cardiac toxicity
Nephrotoxicity

Question 53

Px with Ulcers who need acute gout tx

Answer 53

Colchicine
bc the px does not tolerate NSAIDs or Glucocorticoids

Question 54

Muscle Relaxant

Answer 54

Methocarbamol

Question 55

T or F: Methocarbamol unlike neuromuscular blocking agents, it dies NOT depress:
Neural condition
Neuromuscular transmission
Muscle excitability

Answer 55

T

Question 56

Binds to tubular subunits and inhibits their polymerization → inhibiting phagocytosis

Answer 56

Colchincine

Question 57

When should Colchincine tx be started

Answer 57

> 24-36hrs AFTER symptom onset

Question 58

NSAIDs used to tx Gout

Answer 58

Naproxen
Sulindaco
Celecoxib

Question 59

At what age is NSAID use NOT contraindicated

Answer 59

≥12yo