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immuno abx > Immunosupression > Flashcards

Immunosupression Flashcards

1
Q

corticosteroid MOA

A

1) prostaglandin 2)lymphocyte 3)phagocytosis

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2
Q

Cyclophsophamide

A

cytotoxic, alkylates guanine

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3
Q

mycophenolate mofetil

A

inhibits im pdh, prevents guanine synthesis (CT drug)

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4
Q

azathioprine

A

6-mercaptopurine. block de novo purine synthesis. TPMT

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5
Q

methotrexate

A

dihydrofolate reductase (DHFR) get macrocytic megaloblastic anaemia)

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6
Q

Plasmapheresis

A

remove Ab or enxchange plasma

  1. ab mediated disease (MG, GP)
  2. Ab mediated rejection
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7
Q

Tacrolimus

A

Calcineurin inhibitor (IL-2) transplant rejection

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8
Q

cyclosporin

A

Calcineurin inhibitor

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9
Q

sirolimus

A

calcineurin

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10
Q

tofacitinib

A

JAK inhibitor (RA)

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11
Q

apremilast

A

PDE4 inhibitor (psoriasis)

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12
Q

Basilixab

A

anti-CD25 (IL2) allograft rejection

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13
Q

abatercept

A

anti-CTLA4 (RA)

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14
Q

rituximab

A

anti-CD20 (leukocyte migration) lymphoma, RA, SLE

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15
Q

natalizumab

A

anti-alpha4 intergin (relapse remitting MS, crohns)

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16
Q

tocilzumab

A

anti-IL6 (castle mans, RA)

17
Q

Muromonab-CD3

A

Block CD3, active allograft rejection

18
Q

anti-thymocyte globulin (ATG)

A

causes lymphocyte depletionallograft rejection

19
Q

Daclizumab

A

IL-2 receptor Ab, target CD25 (organ transplant rejection)

20
Q

efalizumab

A

anti CDIIa

21
Q

alemtuzemab

A

monoclonal abs binds to CD52 (CLL, MS)

22
Q

infliximab

A

anti-tif alpha (RA, AS, Psoriasis, IBD)

23
Q

certolizumab

A

anti TNF alpha

24
Q

etancerpet

A

TNF alpha/ TNF beta fusion protien

25
Q

Golimumab

A

TNF alph

26
Q

Ustekinumab

A

anti-IL12 and anti-IL23 (psoriasis)

27
Q

Secukimumab

A

anti-IL17A (psoriasis)

28
Q

Denosumab

A

anti-RANK ligand (osteoporosis, MM, bone mets)

immuno abx (3 decks)

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