Immunosupression

Question 1

Cyclosporin MOA

Answer 1

Calcineurin Inhibitor - Binds to Cyclophilin and blocks T-cell activation by preventing transcription of IL-2

Question 2

Cyclosporin Toxicity

Answer 2

Highly Nephrotoxic

HTN, Hyperlipidemia, neurotoxicity, gingival hyperplasia, hirsutism

Question 3

Tacrolimus MOA

Answer 3

Calcineurin Inhibitor - Binds to FK506 binding protein and blocks transcription of IL-2

Question 4

Tacrolimus Toxicity

Answer 4

Highly Nephrotoxic

increased risked of diabetes and neurotoxicity

Question 5

What is Calcineurin

Answer 5

a protein phosphatase that allows NFAT to enter nucleus - causing transcription of IL-2 genes

Question 6

Sirolimus MOA

Answer 6

mTOR inhibitor - binds FKBP, which prevents response to IL-2

Question 7

Sirolimus Toxicity

Answer 7

NOT Nephrotoxic

Anemia, thrombocytopenia, insulin resistance, hyperlipidemia

Question 8

Daclizumab, Basilixumab MOA

Answer 8

Blocks the IL-2 Receptor

Question 9

Azothioprine MOA

Answer 9

Antimetabolite precursor of 6-Mercaptopurine, blocks nucleotide synthesis to prevent lymphocyte production

Question 10

Azothioprine Toxicity

Answer 10

Leukopenia, Thrombocytopenia, Anemia

Toxicity is increased by Allopurinol, which prevent Xanthine Oxidase from degrading 6-MP.

Question 11

Mycophenolate Mofetil MOA

Answer 11

Inhibits Inosine Monophosphate Dehydrogenase

Question 12

Glucocorticoids MOA

Answer 12

Inhibits NF-kB