Immunosuppressives

Question 1

Simulect (basiliximab)

Answer 1

Induction immunosuppression
Non-depleting
Prevent t lymphocyte proliferation by sitting in CD25 receptor and hindering IL-2 release (block signal 3)

Question 2

Alemtuzumab

Answer 2

Induction immunosuppression
(Depleting)
CD52 depletion of Tcells to prevent nucleotide production

Question 3

Azothioprine

Answer 3

Maintenance immunosuppression
Inhibition on DNA & RNA protein synthesis&raquo_space; inhibit lymphocyte proliferation
Leukopenia

Question 4

Cell cept MMF

Answer 4

Maintenance immunosuppression

Prodrug metabolized the active mycophenlate acid

Question 5

Myfortic

Answer 5

Maintenance immunosuppression

MPA inhibits IMPDH which interferes with purine metabolism required for lymphocyte development

Question 6

CNI (tacrolimus & cyclosporine)

Answer 6

Maintenance immunosuppression

Inhibit calcineurin&raquo_space; reduction in transcription of cytokine genes needed to activate T-cells

Question 7

Glucocorticoids

Answer 7

Maintenance immunosuppression

Inhibit IL-1 and IL-2 to decrease activation and proliferation of T cells

Question 8

Sirolimus

Answer 8

IL-2 stimulates mtor to activate kinase enzymes that promote cell division

Question 9

Belatacept

Answer 9

Co-stimulation blocker prevents T cell interaction with CD28 to inhibit

Question 10

ATGAM or thymoglobulin

Answer 10

Induction immunosuppression (depleting)
Coat host T cells which are destroyed by complement
On for under 7 days
Long term leukopenia