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Immune > Drug Interactions > Flashcards

Drug Interactions Flashcards

1
Q

Fluconazole -CNI

A

increase CNI conc

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2
Q

Phenytoin -CNI

A

Decrease CNI conc

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3
Q

Echinacea -CNI

A

Decrease CNI conc

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4
Q

Rifampin-CNI

A

Decrease CNI conc

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5
Q

Verapamil -CNI

A

Increase CNI conc

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6
Q

Caspofungin-CNI

A

Decrease CNI conc

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7
Q

St. John’s wart-CNI

A

decrease CNI conc

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8
Q

Rifabutin -CNI

A

Decrease CNI conc

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9
Q

Grapefruit juice-CNI

A

Increase CNI conc

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10
Q

Ritonavir -CNI

A

Increase CNI conc

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11
Q

Omeprazole -CNI

A

Increase CNI conc

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12
Q

Clarithromycin -CNI

A

Increase CNI conc

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13
Q

Mag & Al -CNI

A

Increase CNI conc

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14
Q

Terbinafine-CNI

A

Decrease CNI conc

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15
Q

Carbamazepine-CNI

A

Decrease CNI conc

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16
Q

Phenobarbital -CNI

A

Decreased CNI conc

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17
Q

Octreotide-CNI

A

Decrease CNI conc

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18
Q

Statins-CNI

A

Decreased clearance of statins (increased rhabdo)

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19
Q

Dabigitran-CNI

A

Increased exposure

20
Q

NSAIDS-CNI

A

Increased nephrotoxicity

21
Q

Ciprofloxacin-CNI

A

Increased nephrotoxicity

22
Q

Ampho B-CNI

A

Increased nephrotoxicity

23
Q

Digoxin-CNI

A

Digoxin toxicity

24
Q

Diltiazem -CNI

A

Increase CNI conc

25
Q

Al & mag- MPA

A

Decreased MPA absorption

26
Q

Sevelamer & phosphate binders- MPA

A

Decreased MPA absorption

27
Q

PPIs- MPA

A

Only with MMF

Decreased MPA solubility (decreased absorption )

28
Q

Acyclovir/ganciclovir-MPA

A

Concern with decreasing renal function! Monitor

29
Q

COC- MPA

A

Decreased efficacy of COC

Need backup

30
Q

Phenytoin-MPA

A

Albumin binding may be altered

31
Q

COC-glucocorticoid

A

Inhibit glucocorticoid metabolism (higher conc)

32
Q

Erythromycin & clarithromycin - glucocorticoid

A

Increased glucocorticoid conc

33
Q

Ketoconazole - glucocorticoid

A

Increased glucocorticoid conc

34
Q

Naproxen -glucocorticoid

A

Increased glucocorticoid conc

35
Q

Phenytoin-glucocorticoid

A

Decreased glucocorticoid conc

36
Q

Phenobarbital - glucocorticoid

A

Decreased glucocorticoid conc

37
Q

Rifampin - glucocorticoid

A

Decreased glucocorticoid conc

38
Q

Carbamazepine -glucocorticoid

A

Decreased glucocorticoid conc

39
Q

Tacrolimus -glucocorticoid

A

Decreased tacrolimus conc

40
Q

Cyclosporine -glucocorticoid

A

Decreased cyclosporine conc

41
Q

MPA- glucocorticoid

A

Decreased MPA conc

42
Q

Tacrolimus-MPA

A

Higher MPA AUC

43
Q

Cyclosporine-MPA

A

Reduced MPA AUC

44
Q

Cholestyramine-MPA

A

Reduced MPA AUC

45
Q

Antibiotics-MPA

A

Reduced MPA AUC

Immune (4 decks)

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