Drug Interactions Flashcards by alyssa cascio

Q

Fluconazole -CNI

A

increase CNI conc

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Q

Phenytoin -CNI

A

Decrease CNI conc

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Q

Echinacea -CNI

A

Decrease CNI conc

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Q

Rifampin-CNI

A

Decrease CNI conc

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Q

Verapamil -CNI

A

Increase CNI conc

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Q

Caspofungin-CNI

A

Decrease CNI conc

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Q

St. John’s wart-CNI

A

decrease CNI conc

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Q

Rifabutin -CNI

A

Decrease CNI conc

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Q

Grapefruit juice-CNI

A

Increase CNI conc

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Q

Ritonavir -CNI

A

Increase CNI conc

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Q

Omeprazole -CNI

A

Increase CNI conc

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Q

Clarithromycin -CNI

A

Increase CNI conc

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Q

Mag & Al -CNI

A

Increase CNI conc

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Q

Terbinafine-CNI

A

Decrease CNI conc

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Q

Carbamazepine-CNI

A

Decrease CNI conc

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Q

Phenobarbital -CNI

A

Decreased CNI conc

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Q

Octreotide-CNI

A

Decrease CNI conc

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Q

Statins-CNI

A

Decreased clearance of statins (increased rhabdo)

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Q

Dabigitran-CNI

A

Increased exposure

Q

NSAIDS-CNI

A

Increased nephrotoxicity

Q

Ciprofloxacin-CNI

A

Increased nephrotoxicity

Q

Ampho B-CNI

A

Increased nephrotoxicity

Q

Digoxin-CNI

A

Digoxin toxicity

Q

Diltiazem -CNI

A

Increase CNI conc

Q

Al & mag- MPA

A

Decreased MPA absorption

Q

Sevelamer & phosphate binders- MPA

A

Decreased MPA absorption

Q

PPIs- MPA

A

Only with MMF

Decreased MPA solubility (decreased absorption )

Q

Acyclovir/ganciclovir-MPA

A

Concern with decreasing renal function! Monitor

Q

COC- MPA

A

Decreased efficacy of COC

Need backup

Q

Phenytoin-MPA

A

Albumin binding may be altered

Q

COC-glucocorticoid

A

Inhibit glucocorticoid metabolism (higher conc)

Q

Erythromycin & clarithromycin - glucocorticoid

A

Increased glucocorticoid conc

Q

Ketoconazole - glucocorticoid

A

Increased glucocorticoid conc

Q

Naproxen -glucocorticoid

A

Increased glucocorticoid conc

Q

Phenytoin-glucocorticoid

A

Decreased glucocorticoid conc

Q

Phenobarbital - glucocorticoid

A

Decreased glucocorticoid conc

Q

Rifampin - glucocorticoid

A

Decreased glucocorticoid conc

Q

Carbamazepine -glucocorticoid

A

Decreased glucocorticoid conc

Q

Tacrolimus -glucocorticoid

A

Decreased tacrolimus conc

Q

Cyclosporine -glucocorticoid

A

Decreased cyclosporine conc

Q

MPA- glucocorticoid

A

Decreased MPA conc

Q

Tacrolimus-MPA

A

Higher MPA AUC

Q

Cyclosporine-MPA

A

Reduced MPA AUC

Q

Cholestyramine-MPA

A

Reduced MPA AUC

Q

Antibiotics-MPA

A

Reduced MPA AUC