IMMUNOSUPPRESSANTS Flashcards
what are immunosuppresants used for?
agents that dimish the immune system
- prevent transplant rejection
- to help offset the effects of autoimmune disorders such as rheumatoid arthritis or lupus
immunosuppresants are given at the time of transplatation and continued for _______ following surgery to prevent a rejection.
months or even years
treatment for autoimmune disorders… given drugs in high doses for ____or low doses for ___.
brief periods in high doses to control relapse
low doses for long term
____ and ___ are the “gold standard” in the prevention of transplant rejection and they are also ___.
cyclosporine and tacrolimus
calcineurin inhibitors
what is the AE for tacrolimus?
kidney toxicity**
hyperglycemia
neurotoxicity
what are the AE for cyclosporine?
kidney toxicity**
gingivitis
hypertension
____ is 100 times more potent than ____ and may be more effective for some patients getting transplants.
tacrolimus is 100 times more potent than cyclosporine
which calcineurn inhibitor is used for severe RA and xerophthalmia (dimished tear production=restasis)?
cyclosporine
what is the one thing tacrolimus is used for that is different?
graft vs host disease
if taking cyclosporine and have liver impairment, they have have a ___.
LOWER DOSE
which calcineurn inhibitor should you take on empty stomach and which one should/could you take with milk,chocolate milk, OJ?
empty stomach- tacrolimus
milk-cyclosporine
should you avoid grapefruit juice with calcineurn inhibitors?
YES
what depresses the immune system and inflammatory response?
corticosteroids
