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step 1 - immuno > immunosuppressants > Flashcards

immunosuppressants Flashcards

1
Q

cyclosporine MOA?

A

calcineurin inhibitor, binds cyclophilin

prevents IL2 transcription

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2
Q

cyclosporine use?

A

txp rejection ppx
psoriasis
RA

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3
Q

cyclosporine toxicity?

A

NEPHROTOXIC
HTN
hyperlipidemia
neurotoxicity

** gingival hyperplasia, hirsutism

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4
Q

tacrolimus MOA?

A

calcineurin inhibitor, binds FKBP

prevents IL2 transcription

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5
Q

tac use?

A

txp rejection ppx

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6
Q

tac toxicity?

A

like cyclosporine but w/o gingival hyperplasia/hirsutism

** increased risk of diabetes and neurotoxicity

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7
Q

sirolimus (rapamycin) MOA?

A

mTOR inhibitor

prevents response to IL2

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8
Q

sirolimus use?

A

kidney txp rejection ppx

synergistic with cyclosporine

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9
Q

sirolimus toxicity?

A 
anemia
TCP
leukopenia
insulin resistance
hyperlipidemia
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10
Q

daclizumab, basiliximab?

A

monoclonal Abs that block IL2R

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11
Q

azathioprine MOA?

A

6MP precursor, blocks nucleotide synthesis

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12
Q

azathioprine use?

A 
txp rejection ppx
RA
Crohn
glomerulonephritis
autoimmune
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13
Q

azathioprine toxicity?

A

leukopenia
anemia
TCP

** toxicity increased by allopurinol

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14
Q

glucocorticoid MOA?

A

inhibit NFKB - decreases transcription of many cytokines

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15
Q

aldesleukin?

A

IL 2
used in renal cell carcinoma
metastatic melanoma

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16
Q

filgrastim

A

G-CSF

17
Q

sargramostim

A

GM-CSF

18
Q

romiplostim, eltrombopag

A

used in TCP

19
Q

oprelvekin

A

IL 11

used in TCP

20
Q

alemtuzumab?

A

–>CD52

used in CLL

21
Q

bevacizumab?

A

–>VEGF

used in CRC, renal cell carcinoma

22
Q

cetuximab?

A

–> EGFR

used in stage IV CRC, head/neck ca

23
Q

rituximab?

A

–> CD20

used in BCell NHL, CLL, RA, ITP

24
Q

trastuzumab?

A

–>HER2neu

used in brca

25
Q

adalimumab, infliximab?

A

–>TNF-a

used in IBD, RA, ankylosing spondylitis, psoriasis

26
Q

eculizumab?

A

–>C5 (complement)

used in PNH

27
Q

natalizumab?

A

–>alpha 4 integrin
used in MS, Crohn

** risk of PML in pts with JC virus

28
Q

abciximab?

A

–> IIb/IIIa

used in patients getting PCI

29
Q

denosumab?

A

–> RANKL

used in osteoporosis

30
Q

digoxin immune Fab?

A

antidote for dig toxicity

31
Q

palivizumab?

A

–> RSV F protein

used for RXV ppx in high risk infants

32
Q

ranibizumab?

A

–> VEGF

used in neovascular macular degeneration

step 1 - immuno (4 decks)

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