Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

pharmacology > Immunopharmacology > Flashcards

Immunopharmacology Flashcards

1
Q

What is MoA of Glucocorticoids?

A

Bind to cytosolic receptors
Cytotoxic T lymphocytes and macrophages inhibited
Antigen-presenting cells inhibited

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is MoA of Cyclosporine?

A

Calcineurin inhibitor
Cyclosporine forms a complex with cyclophilin
The complex inhibits calcineurin phosphatase activity
Prevents NFAT dephosphorylation
T lymphocyte fails to respond to antigenic stimulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the use of Cyclosporine?

A

Organ transplantation
Rheumatoid arthritis
Psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the ADR of Cyclosporine?

A 
Renal dysfunction
Hypertension
Hyperlipidemia
Hyperglycemia
Gum hyperplasia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drugs increase cyclosporine levels? What drugs decrease?

A

Increase- Ca2+ channel blockers (verapamil) because they reverse efflux pump and P450 inhibitors.
Decrease- P450 inducers. Never give along with tacrolimus because enhances renal toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is MoA of Tacrolimus?

A

Calcineurin inhibitor

Tacrolimus forms a complex with immunophilin then follows same mechanism as cyclosporine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the use of Tacrolimus?

A

Prophylaxis of solid-organ allograft rejection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the ADR of Tacrolimus?

A

Hyperglycemia more than cyclosporine
Nephrotoxicity
Hypertension
Neurotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is MoA of Sirolimus?

A

mTOR inhibitor

Binds to FKBP-12- inhibits T-lymphocyte activation and proliferation downstream of the IL-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the use of Sirolimus?

A

Prophylaxis of organ transplant rejection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the ADR of Sirolimus?

A

BM depression
Increase in serum cholesterol and triglycerides
Hyperglycemia
Because no renal toxicity, is the first line drug to prevent renal transplant rejection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is MoA of Mycophenolate Mofetil?

A

IMP dehydrogenase inhibitor

Prevents B and T cell proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the use and ADR of Mycophenolate Mofetil?

A

Use- for prophylaxis of transplant rejection

ADR- Reversible BM depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is MoA and use of Levamisole?

A

Restores depressed immune function of B & T cells

Adjuvant therapy with 5-fluorouracil after surgical resection in patients with colon cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the use of Thalidomide?

A

Erythema nodosum leprosum and in multiple myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the use of Bacillus Calmette-Guerin?

A

Prophylaxis of carcinoma in situ of the urinary bladder

17
Q

What are some anti-TNF Reagents?

A

Infliximab- monoclonal antibody
Etanercept- fusion protein, mimics TNF receptor to bind to free TNF or membrane-bound TNF
Used for Rheumatoid arthritis and Crohn’s disease

pharmacology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions