Hypothalamic and pituitary hormones

Question 1

What is mecasermin?

Answer 1

Recombinant IGF-1, simulates IGF-1 receptors

Restores growth in pts with GH receptor mutation or IGF-1 deficiency resistant to GH.

Question 2

What is pegvisomant?

Answer 2

Blocks GH receptor
Decreases effects of excess GH
Tx- Acromegaly

Question 3

What is atosiban?

Answer 3

Blocks oxytocin receptor
Decreases uterine contractions
Used for preterm labor

Question 4

Lithium side effect- in kidney ? In thyroid ?

Answer 4

Kidney- nephrogenic diabetes insipidus

Thyroid- hypothyroidism

Question 5

What drugs cause SIADH?

Answer 5

Vinblastine, Vincristine
SSRI, MAOI, TCA
Carbamazepine

Question 6

What visual field defect is caused if optic chiasm is damaged by pituitary adenoma? What drug can you use to treat?

Answer 6

Bitemporal hemianopia

Tx- bromocriptine

Question 7

Which kind of pituitary adenoma need surgery?

Answer 7

Macroadenoma of pituitary- trans-sphenoidal approach

Question 8

Why is desmopressin used to treat bleeding disorders?

Answer 8

Activates vasopressin- in kidney decreases excretion of water. Outside of kidney increases factor 8 and von willebrand factor. Also treats nocturnal enuresis.

Question 9

What drug can treat primary enuresis?

Answer 9

Desmopressin