Immunopharm Drugs

Question 1

Sirolimus

Answer 1

MOA: Binds FKBP-12 and inhibits mTOR, T cell proliferation

SAE: Increases cholesterol, triglycerides; bone marrow suppression, hepatotoxicity

Question 2

Rituximab

Answer 2

MOA: mAb that binds CD20 on B cells and mediates lysis

SAE: anemia, neutropenia

Question 3

Prednisone (glucocorticoid)

Answer 3

MOA: GR dependent changes in gene expression and cell signaling lead to inhibition of leukotriene and prostaglandin synthesis, inhibition of leukocyte function and leukocyte trafficking

SAE: many toxicities if used chronically (osteoporosis, muscle wasting, diabetes, adrenal suppression)

Question 4

Mycophenolate Mofetil

Answer 4

MOA: inhibits inosine monophosphate dehydrogenase and GTP synthesis

SAE: bone marrow suppression

Question 5

Methotrexate

Answer 5

MOA: part of inflammatory effect due to enzyme inhibition that leads to high levels of extracellular adenosine and adenosine receptor activation; also a DHFR reductase inhibitor used in cancer chemo

SAE: Bone marrow suppression

Question 6

Ibuprofen

Answer 6

MOA: Non-specific COX inhibitor

SAE: nephrotoxicity, some GI toxicity

Note: naproxen has longer half-life

Question 7

Etanercept

Answer 7

MOA: Decoy receptor for TNF-alpha (works like an mAB)

SAE: injection site reactions

Question 8

Cyclosporine

Answer 8

MOA: binds cyclophillin and inhibits calcineurin and NFAT activation

SAE: nephrotoxicity, neurotoxicity, hypertension

Question 9

Aspirin

Answer 9

MOA: non-specific COX inhibitor, causes covalent inactivation of COX

SAE: GI ulceration/bleeding, rare nephrotoxicity

Question 10

Anakinra

Answer 10

MOA: Recombinant version of an endogenous IL-1 receptor antagonist

SAE: Increased risk of infections

Notes: Used to treat rheumatoid arthritis