Anti-parasite Drugs

Question 1

Metronidazole

Answer 1

MOA: forms intermediates which then destroy DNA

SAE: headache, peripheral neuropathy, alcohol sensitivity

Notes: antiprotozoal

Question 2

Chloroquinolone

Answer 2

MOA: prevents heme polymerization to hemozoin and detoxification

SAE: GI distress, skin rash, headaches

Note: antiprotozoal

Question 3

Artemisinins

Answer 3

MOA: uncertain; metabolized to toxic free radicals

SAE: GI distress

Note: antiprotozoal

Question 4

Quinine

Answer 4

MOA: uncertain; may prevent heme polymerization to hemozoin and detoxification

SAE: GI distress, headache, vertigo, blurred vision

Note: antiprotozoal

Question 5

Atovaquone

Answer 5

MOA: disrupts mitochondrial electron transport

SAE: GI distress

Note: antiprotozoal

Question 6

Pyrimethamine (proguanil)

Answer 6

MOA: inhibits protozoal DHFR

Note: antiprotozoal

Question 7

Albendazole

Answer 7

MOA: inhibits microtubule assembly

SAE: leukopenia w/ prolonged use

Note: antihelminthic

Question 8

Ivermectin

Answer 8

MOA: increases GABA-mediated inhibition and causes immobilization

SAE: reactions to dying worms

Note: antihelminthic

Question 9

Mebendazole

Answer 9

MOA: inhibits microtubule synthesis

SAE: GI distress

Note: antihelminthic

Question 10

Praziquantel

Answer 10

MOA: increases membrane permeability to calcium, causing paralysis

Note: antihelminthic