Immunomodulator Agents

Question 1

Selective inhibitors of cytokines production

Answer 1

• Calcineurin Inhibitors ( cyclosporine and tacrolimus )

- mTOR inhibitors ( sirolimus and everolimus )

Question 2

Immunophilins bound with calcineurin inhibitors

Answer 2

Cyclosporine with - cyclophilin -

Tacrolimus with - FKBP 12 ( FK binding protein )

Question 3

Glucocorticoids MoA, Therapeutic uses, and side effects

Answer 3

Names:
Prednisone and Methylprednisone

MoA:
Redistribution or lushes of lymphocytes
Down regulation of cytokines production
Increase fractional catabolic rate of IgG

Untoward effect:
Gross retardation children 
avascular necrosis of bone 
osteoporosis 
infections 
delayed the poor wound healing 
hypoglycemia 
hypertension 
cataract

Question 4

Antimetabolite names

Answer 4

Mycophenolate Mofetil + Azathioprine

Question 5

Immunosuppressive Antibodies

Answer 5

Polyclonal Antibodies

ATG - rabbit

ALG - equine

Monoclonal Antibodies

Anti Cd3= MUROmonab ( murine)
Anti IL2 = dacliZUmab (humanized) , BasiliXimab ( Chimera )
Anti CD25 = alemtuZUmab( Humanized )