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MLS Blood Bank > Immunoloy > Flashcards

Immunoloy Flashcards

1
Q

What is characteristic of a primary response compared to a secondary response?

A

More IgM antibodies are produced in the primary response

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2
Q

Which cell is capable of immunologic memory?

A

B lymphocytes (B cells)

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3
Q

What is known as the helper T cell?

A

CD4

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4
Q

What is know as the cytoxic T cell?

A

CD8

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5
Q

this is the region that binds to the receptors on phagocytic cells:

A

FC fragment

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6
Q

This is the region has the antibody binding site?

A

FAB

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7
Q

The portion of an immunoglobulin molecule that controls antigen binding to the antibody:

A

the variable sequences in the V region

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8
Q

Which cells are involved in cell mediated immunity?

A

T-Cells

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9
Q

Which cells are involved in humoral mediated immunity?

A

B-Cells

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10
Q

The type of immunity that follows the injection of an immunogenic (vaccination) is termed:

A

artificial active immunity

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11
Q

Individual infected with mircororganims produces Ab (clinical or subclinical infection)

A

Naturally acquired active immunity

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12
Q

Individual protected by abs produced by another person (maternal abs that cross placenta and are present in breast milk)

A

Naturally acquired passive immunity

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13
Q

individual received immune globulin containing abs produced by another person (Rhogam)

A

Artificically acquired passive immunity

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14
Q

A reactive total anti-HBc and reactive HBsAg indicate what about the hepatitis infection?

A

Chronic HBV infection

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15
Q

HBsAg and HBeAg postive indicate what?

A

acute infection

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16
Q

Anti- HBe and Anti HBs indicate what?

A

recovery

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17
Q

What pathway is Ab indepent. Activated by bacteria, fungi, viruses, tumor cells, some parasites?

A

Alternative pathway

18
Q

What path way is triggered by ag/ab rxn. IgM is most efficient activator?

A

Classical pathway

19
Q

What are the functions of complement pathway?

A

inflammation, opsonization, chemotaxis, cell lysis

20
Q

C5-C9 are which part of the the pathway?

A

Membrane attack complex (lysis)

21
Q

Cells that can act as antigen presenting cells for exogenous antigens include?

A

B lymphocytes

22
Q

This enhances cytolytic activity of lymphokine-activated killer cells (LAK)

A

IL-2

23
Q

Defense mechanism present at birth. not ag specific

A

innate or natural immunity

24
Q

Defense mechanism that are antigen specific

A

adaptive or acquired immunity

25
Q

What is characteristic of an anamnestic repsonse versus a primary response?

A

Has a longer plateau

26
Q

What can cause a false VRDL test?

A

SLE

27
Q

The major clinical manifestation of a B-cell deficiency is:

A

recurrent bacterial infections

28
Q

what type of sensitivity invovles IgE and anaphylaxis?

A

Type 1

29
Q

What type of sensitivity involves AB mediated cells surface reactions?on the surface of cells (hematuria and decreased Hgb)
Transfusion reactions, hemolytic disease of newborn, autoimmune hemolytic anemia

A

Type II

30
Q

This type of hypersensitivity is in the tissues?

SLE and RA

A

Type III

31
Q

This type of hypersensitivity is cell mediated?

Contact dermatitis, hypersensitivity pneumonitis, TB skin test

A

Type IIII

32
Q

These cells recognize target cells in the absence of MHC proteins?

A

NK cells

33
Q

A syphillis test that detects specific treponemal antibodies?

A

FTA-ABS

34
Q

Prozone is an excess of what?

A

antibody

35
Q

Postzone is an excess of what?

A

antigen

36
Q

The serum of a patient who recieved all doses of the hepatitis B vaccine should contain:

A

anti-HBs

37
Q

A decreased CH50, normal C3 and C4 levels is a problem in which part of the pathway?

A

C5-C9

38
Q

What immunoglobulins are expressed on the surface of a mature unstimulated B lymphocyte?

A

IgD and IgM

39
Q

Which complement regulatory protein acts to prevent initial complement activation?

A

C1 inhibitor

40
Q

What disease has depostitions of immune complexes in the kidney?

A

SLE

41
Q

What auto-immune disorder is indicated by an increased titer of anti-Sm (anti-smith) antibodies?

A

SLE systemic lupus erythematosus

MLS Blood Bank (2 decks)

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