Immunology Quiz Flashcards

1
Q

A lymphoblast can produce which of the following blood cells?

a) Platelets

b) Immature T cells

c) Red blood cells

d) Monocytes

e) Immature B cells

A

b) Immature T cells

e) Immature B cells

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2
Q

Which of the following are correct with respect to the bone marrow?

a) It contains pluripotent haematopoietic stem cells

b) It releases mature B and T cells

c) It contains mature B cells

d) It is the major site of blood cell production in adults

e) It contains myeloid and lymphoid progenitor cells

A

a) It contains pluripotent haematopoietic stem cells

c) It contains mature B cells

d) It is the major site of blood cell production in adults

e) It contains myeloid and lymphoid progenitor cells

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3
Q

Which of the following are correct with respect to B cells?

a) They mature as soon as they reach secondary lymphoid tissue

b) They are responsible for immune surveillance

c) They are known as transitional B cells until they mature

d) They must encounter their antigen marker in order to mature

e) They undergo apoptosis if they do not encounter their specific antigen

A

b) They are responsible for immune surveillance

c) They are known as transitional B cells until they mature

d) They must encounter their antigen marker in order to mature

e) They undergo apoptosis if they do not encounter their specific antigen

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4
Q

Lymphocytes…

a) can be either T cells or B cells

b) mature in the thymus gland

c) are found in the tissues

d) are found in the circulation

A

a) can be either T cells or B cells

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5
Q

T cells…

a) can be either T cells or B cells

b) mature in the thymus gland

c) are found in the tissues

d) are found in the circulation

A

b) mature in the thymus gland

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6
Q

Monocytes…

a) can be either T cells or B cells

b) mature in the thymus gland

c) are found in the tissues

d) are found in the circulation

A

d) are found in the circulation

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7
Q

Macrophages…

a) can be either T cells or B cells

b) mature in the thymus gland

c) are found in the tissues

d) are found in the circulation

A

c) are found in the tissues

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8
Q

Which of the following statements are correct?

a) During red cell recycling peptides from the red cell membrane are presented by macrophages

b) Phosphatidylserine is normally present on the extracellular surface of the red cell membrane

c) Red cells are most likely targeted for recycling because of sustained membrane damage during their life-span

d) Macrophages have a receptor for phosphatidylserine

e) Presentation of -non-self’ peptides can trigger T cell activation

A

a) During red cell recycling peptides from the red cell membrane are presented by macrophages

c) Red cells are most likely targeted for recycling because of sustained membrane damage during their life-span

d) Macrophages have a receptor for phosphatidylserine

e) Presentation of -non-self’ peptides can trigger T cell activation

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9
Q

Select the correct statement; in order to become activated, B cells…?

a) must have bound their target antigen

b) must migrate to the secondary lymphoid tissues

c) do not require the help of an activated T cell

d) require the help of an activated T cell

e) do not require their target antigen to be bound

A

a) must have bound their target antigen

b) must migrate to the secondary lymphoid tissues

d) require the help of an activated T cell

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10
Q

Which of the following statements are correct with respect to plasma cells?

a) They differentiate from B cells

b) They differentiate from T cells

c) They secrete antibody

d) They differentiate from macrophages

e) They can persist in the body for many years

A

a) They differentiate from B cells

c) They secrete antibody

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11
Q

Which of the following statements are correct with respect to memory cells?

a) They can persist in the body for many years

b) They differentiate from B cells

c) They need to encounter their target antigen to replicate

d) They secrete antibody

e) They differentiate from T cells

A

a) They can persist in the body for many years

b) They differentiate from B cells

c) They need to encounter their target antigen to replicate

d) They secrete antibody

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12
Q

Which of the following statements are correct with respect to red cell membrane proteins?

a) Spectrin, Ankyrin and 4.2 are all examples of peripheral proteins

b) Spectrin, Ankyrin and 4.2 are all examples of integral proteins

c) Integral proteins are transmembrane and extracellular

d) Peripheral proteins are found in the internal cytoplasm domain of the red cell

e) Spectrin, GPA and 4.2 are all examples of peripheral proteins

A

a) Spectrin, Ankyrin and 4.2 are all examples of peripheral proteins

c) Integral proteins are transmembrane and extracellular

d) Peripheral proteins are found in the internal cytoplasm domain of the red cell

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13
Q

Which of the following statements are correct with respect to immunogenicity of a substance entering a host?

a) Only protein or carbohydrate substances would potentially lead to an immune response

b) The larger the amount present the greater chance of an immune response

c) It needs to be relatively large in size

d) It needs to be recognised as foreign to that host

e) It may be protein, carbohydrate or lipid in nature

A

b) The larger the amount present the greater chance of an immune response

c) It needs to be relatively large in size

d) It needs to be recognised as foreign to that host

e) It may be protein, carbohydrate or lipid in nature

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14
Q

Select the correct statements.
Production of blood group antibodies can occur following:

a) Pregnancy

b) Transfusion of PLT components

c) Transfusion of RBC components

d) Transfusion of FFP

e) Allogeneic transplantation

A

a) Pregnancy

b) Transfusion of PLT components

c) Transfusion of RBC components

e) Allogeneic transplantation

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15
Q

Select the correct statements.
The immunoglobulin class of blood group antibodies can be?

a) IgA

b) IgE

c) IgG

d) IgD

e) IgM

A

a) IgA

c) IgG

e) IgM

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16
Q

Which of the following are correct with respect to the Fc portion of IgG?

a) It is involved in placental transfer

b) It is where antigen binding takes place

c) It is where antihuman globulin (AHG) binds when used in serological testing

d) It can be initiate complement activation

e) It is part of the molecule that is recognised by macrophages

A

a) It is involved in placental transfer

c) It is where antihuman globulin (AHG) binds when used in serological testing

d) It can be initiate complement activation

e) It is part of the molecule that is recognised by macrophages

17
Q

Which of the following are correct with respect to the hinge region of the immunoglobulin molecules?

a) It contributes to their overall flexibility

b) It aids binding to the target antigen

c) It consists of repeating proline residues only

d) It is part of the light chain

e) It consists of repeating proline residues and disulphide bonds

A

a) It contributes to their overall flexibility

b) It aids binding to the target antigen

e) It consists of repeating proline residues and disulphide bonds

18
Q

Which of the following are correct with respect to ‘a polyclonal response to an antigen…’?

a) Will involve a single B cell becoming activated

b) Will involve multiple B cells becoming activated

c) Occurs if the antigen is comprised of multiple epitopes

d) Occurs as a result of repeated transfusion episodes

e) Occurs if the antigen is comprised of a single epitope

A

b) Will involve multiple B cells becoming activated

c) Occurs if the antigen is comprised of multiple epitopes

19
Q

Which of the following statements are correct?

a) The use of monoclonal blood grouping reagents helps to standardise test results in the transfusion laboratory

b) Where possible blood grouping reagents are deliberately manufactured to be IgG rather than IgM

c) Where possible blood grouping reagents are deliberately manufactured to be IgM rather than IgG

d) A B cell fused with a myeloma cell line is known as a hybridoma

e) A B cell fused with a myeloma cell line can produce indefinitely in culture

A

a) The use of monoclonal blood grouping reagents helps to standardise test results in the transfusion laboratory

c) Where possible blood grouping reagents are deliberately manufactured to be IgM rather than IgG

d) A B cell fused with a myeloma cell line is known as a hybridoma

e) A B cell fused with a myeloma cell line can produce indefinitely in culture

20
Q

Where do T cells mature?

A

Thymus

21
Q

Where does blood cell production in adults happen?

A

Bone marrow

22
Q

Where do you find Kupffer cells?

A

Liver

23
Q

Where are the secondary lymphoid tissues?

A

Lymph nodes and spleen

24
Q

Where are the primary lymphoid tissue in adults?

A

Thymus and bone marrow