Immunology of the GI system Flashcards
Cell that plays a role in immune tolerance by recognizing sugar groups on the outside of cells
T reg cell
Central Immune system uses what type of Th cell?
Surface Immune system?
central - th1
surface (mucosa) - th2
Slide 9. Test Question.
What are the layers of defense in the GI tract?
Intraepithelial Barrier
Lamina Propria
Peyer’s Patch
Mesenteric Lymph nodes
Slide 9. Test Question.
Which layers of defense can make an adaptive response
peyer’s patch and lymph nodes.
can prime t cells ther
Where do most antigens gain entry in the gi system
GALT
What the hell is Beta7?
An integrin. It attracts CD8 cells that are made and they localize to the gut when they bind to beta7
MADCAM-1 is the ligand that binds to beta7 on the cells that localize there
Slide 19 test question
Upper GI tract’s method for defense, probably esophagus
Intraepithelial lymphocytes.
mostly effector cytotoxic t cells.
Slide 32 test question
7 ways to defend pathogens
which types are effective for bacteria, viruses, protozoa?
1 - block entry to organism (most pathogens)
- trefoil factors
2 - block entry to cells (bacteria and viruses)
3 - prohibit spreading (most pathogens) - coagulation, constriction, interferons
4 - direct killing (most pathogens) - complement, ROS
5 - kill infected cell (viruses and intracellular bacteria, protozoa) - interferons, NK cells, cytotoxic t cell.
6 - expulsion (multicellular parasites) - IgE, LT’s, PG’s.
7 - deprive nutrients (bacteria and protozoa) - lactoferrin
Slide 52 test question
2 anti inflammatory mediators
3 pro-imflammatory mediators
anti = IL-10, IL-1ra pro = INF-gama, TNF-alpha, IL-12
Slide 56 test question
Cells/stuff seen in an acute inflammatory process:
TH1 lymphocyte IFN-gamma M1 macrophage IgG and IgA CTL cells NK cells
Slide 63
Inflammatory response to Salmonella
Once it’s in a macrophage, IL-18 –> tells other macrophages to make immune response
TNF and FasL for apoptosis of infected cells
infected cell also secretes INF-gamma –> stimulate Th1 cells
slide 19
Moving down the GI tract, there are more structures dedicated to immune function. There are also more,
bacteria
slide 19
What might be the role of the appendix?
A reservoir for bacteria
immune cells there maintain the environment for it.
Slide 56
Cells/other stuff seen in chronic inflammation:
Th2/Th17 IL-4, IL-17 M2 macrophage IgE Eosinophils Basophils
what allows effector B and T cells made in the peyer’s patches to make their way back to the lining of the GI tract after they go systemic through the thoracic duct
Alpha 4 Beta 7 integrin proteins
