Immunology: Helper T Cell Attack Mechanisms

Question 1

TH1 cell (signature cytokines, immune reactions, host defense, role in diseases)

Answer 1

Signature cytokine: IFNγ
Immune reactions: Macrophage activation; IgG production
Host defense: Intracellular microbes
Role in diseases: Autoimmune diseases; tissue damage associated with chronic infections

Question 2

TH2 cell (signature cytokines, immune reactions, host defense, role in diseases)

Answer 2

Signature cytokines: IL-4, IL-5, IL-13
Immune reactions: Mast cell, eosinophil activation; IgE production; alternative macrophage activation
Host defense: Helminthic parasites
Role in diseases: Allergic diseases

Question 3

TH17 cell (signature cytokines, immune reactions, host defense, role in diseases)

Answer 3

Signature cytokines: IL-17A, IL-17F, IL-22
Immune reactions: Neutrophilic, monocytic activation
Host defense: Extracellular bacteria, fungi
Role in diseases: Autoimmune and inflammatory diseases