Immunology Chp 4 Flashcards
Antibodies produced against one antigen may bind to structurally similar antigens and is called _________.
Cross reaction
Light chain is made of either___________ or ______ but not both of which the first one to be formed is _________.
Kappa or Lambda
made first:Kappa
This receptor must be added to an immature B cell for it to become a mature B cell: ___________.
IgD
The antigen-recognizing portions of the receptors are called the ________ and the conserved portions of the receptors are the _________.
- ) Variable regions
2. ) Constant regions
Each light chain consists of how many ______ variable and how many ______ constant regions?
One
One
_____ is the portion of the Ig molecule that contributes most to antigen binding.
CDR3
Associated with the TCR is a complex of proteins called the _____ and ______ proteins.
CD3
Zeta
There are five types of heavy chains: ____, _____, ____, ____, and ____.
mu, delta, gamma, epsilon, alpha
IgA has ____ antigen-binding sites.
4
IgM is a _______ and has _____ antigen-binding sites
pentamer : 10
Which Antibody isotype is involved in the allergic reaction
IgE
The first Ig protein produced is __________.
IgM
- Diversity of antigen receptors is produced by the use of different combinations of V, D and J gene segments and is called ___________ diversity. Changes in nucleotide sequences introduced at the junctions of V, D and J gene segments is called ________ diversity
Combinatorial : Junctional
True/False? All antigen receptor gene loci contain V, J and C genes
True
When an antibody binds to several antigens of the same type or several epitopes of the same antigen, the total strength of binding will be greater than the affinity of a single antigen-antibody bond and is called ____________________.
Avidity
