Immunology--Autoantibodies

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin, lupus anticoagulant

Answer 3

SLE, antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

Limited scleroderma (CREST syndrome)

Question 5

Anti-desmosome (anti-desmoglein)

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA, Anti-Smith

Answer 6

SLE

Question 7

Anti-glutamic acid decarboxylase (GAD-65)

Answer 7

Type I DM

Question 8

Antihemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Anti-histone

Answer 9

Drug-induced lupus

Question 10

Anti-Jo-I, anti-SRP, anti-Mi-2

Answer 10

polymyositis, dermatomyositis

Question 11

Antimicrosomal, antihyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Antimitochondrial

Answer 12

primary biliary cirrhosis

Question 13

Antinuclear antibodies

Answer 13

SLE, nonspecific

Question 14

Antiparietal cell

Answer 14

Pernicious anemia

Question 15

Anti-Scl-70 (anti-DNA topoisomerase)

Answer 15

Scleroderma (diffuse)

Question 16

Anti-smooth muscle

Answer 16

Autoimmune hepatitis

Question 17

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 17

Sjogren syndrome

Question 18

Anti-TSH receptor

Answer 18

Graves disease

Question 19

Anti-U1 RNP (ribonucleoprotein)

Answer 19

Mixed connective tissue disease

Question 20

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 20

Celiac disease

Question 21

MPO-ANCA/p-ANCA

Answer 21

Microscopic polyangitis, eosinophilic granulmatosis with polyangitis (Churg-Strauss syndrome)

Question 22

c-ANCA/ PR3-ANCA

Answer 22

Granulomatosis with polyangiitis (Wegener)

Question 23

Rheumatoid factor (IgM antibody that targets IgG Fc region), anti-CCP (more specific)

Answer 23

Rheumatoid arthritis