Immunology--Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

Myasthenia gravis

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2
Q

Anti-basement membrane

A

Goodpasture syndrome

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3
Q

Anticardiolipin, lupus anticoagulant

A

SLE, antiphospholipid syndrome

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4
Q

Anticentromere

A

Limited scleroderma (CREST syndrome)

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5
Q

Anti-desmosome (anti-desmoglein)

A

Pemphigus vulgaris

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6
Q

Anti-dsDNA, Anti-Smith

A

SLE

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7
Q

Anti-glutamic acid decarboxylase (GAD-65)

A

Type I DM

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8
Q

Antihemidesmosome

A

Bullous pemphigoid

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9
Q

Anti-histone

A

Drug-induced lupus

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10
Q

Anti-Jo-I, anti-SRP, anti-Mi-2

A

polymyositis, dermatomyositis

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11
Q

Antimicrosomal, antihyroglobulin

A

Hashimoto thyroiditis

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12
Q

Antimitochondrial

A

primary biliary cirrhosis

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13
Q

Antinuclear antibodies

A

SLE, nonspecific

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14
Q

Antiparietal cell

A

Pernicious anemia

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15
Q

Anti-Scl-70 (anti-DNA topoisomerase)

A

Scleroderma (diffuse)

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16
Q

Anti-smooth muscle

A

Autoimmune hepatitis

17
Q

Anti-SSA, anti-SSB (anti-Ro, anti-La)

A

Sjogren syndrome

18
Q

Anti-TSH receptor

A

Graves disease

19
Q

Anti-U1 RNP (ribonucleoprotein)

A

Mixed connective tissue disease

20
Q

IgA anti-endomysial, IgA anti-tissue transglutaminase

A

Celiac disease

21
Q

MPO-ANCA/p-ANCA

A

Microscopic polyangitis, eosinophilic granulmatosis with polyangitis (Churg-Strauss syndrome)

22
Q

c-ANCA/ PR3-ANCA

A

Granulomatosis with polyangiitis (Wegener)

23
Q

Rheumatoid factor (IgM antibody that targets IgG Fc region), anti-CCP (more specific)

A

Rheumatoid arthritis