Immunology Flashcards
1
Q
What are the signs and symptoms of CD vs UC?
A
- CD: abdominal pain, obstruction, fever
- UC: bloody diarrhea, urgency
2
Q
What is the GI involvement of CD vs UC?
A
- CD: mouth to anus (rectum spared)
- UC: colon and/or rectum
3
Q
What is the pathology of CD vs UC?
A
- CD: abscesses, fistulas, strictures, granuloma formation, transmural inflammation
- UC: pseudopolyps, toxic megacolon, mucosal or submucosal inflammation
4
Q
How is the diagnosis made for CD?
A
- “string sign” on barium x ray
- Skip lesions
- “Cobblestone appearance on endoscopy
5
Q
How is the diagnosis made for UC?
A
- Ulcerations
- Edema
- Erythema of colonic mucosa
- Negative stool cultures
- Continuous disease
6
Q
What is the cancer risk in CD vs UC?
A
- CD: increased after 15 years
- UC: increased after 10 years
7
Q
What is the management and treatment of CD vs UC?
A
- CD: Medical because surgical is not curative
- UC: Medical and surgical can be curative
8
Q
What lab test is positive in CD?
A
- ASCA
9
Q
What lab test is positive in UC?
A
- pANCA
10
Q
What combination of lab tests has a high predictive value for CD?
A
- +ASCA and -pANCA
11
Q
What is UC characterized by?
A
- An atypical activation of Th2 cells and natural killer cells
12
Q
What do Th2 and natural killer cells produce?
A
- IL-5 (Th2)
- IL-4 (Th2)
- IL-13 (Th2 and NKT)
13
Q
How does an activated T cell turn into a Th2 cell?
A
- IL-4
