GI infection Pharm

Question 1

What is the treatment of cyclospora cayetanensis?

Answer 1

• TMP-SMZ

- Ciprofloxacin for sulfa-allergic patients

Question 2

What is the treatment of enterobius vermicularis?

Answer 2

• Mebendazole (Albendazole)

Question 3

What is the treatment of Taenia spp.?

Answer 3

• Praziquantel

Question 4

What is the treatment of Strongyloides stercoralis?

Answer 4

• Ivermectin

Question 5

What is the MOA of the benzimidazoles?

Answer 5

• Inhibition of microtubule polymerization via beta tubulin binding (reduced glucose transport)
• Inhibition of mitochondrial fumarate reductase (resulting in immobilization and death)

Question 6

What is the MOA of ivermectin?

Answer 6

• Binds selectively and with high affinity to glutamate gated chloride ion channels
• Induces a hyperpolarization resulting in a tonic paralysis of worms’ nerves/musculature (resulting in immobilization and death)

Question 7

What is the MOA of praziquantel?

Answer 7

• Increases cell membrane permeability resulting in loss of intracellular calcium, massive contractions ending in paralysis of musculature
• Disintegration of schistosome tegument followed by attachment of phagocytes leading to death