Immunology Flashcards
what are the first responders of WBC’s
Neutrophils
what percent of WBCs are neutrophils
40-75%
what does a neutrophil lobe look like
multi lobed nucleus polys
what is in PUS
a mixture of dead neutrophils
what does neutrophils contain
lysosomes with hydrolytic enzymes and oxidase
what percent of WBC’s are basophils
0.5%
what do basophils do
mediate allergic reaction
what three things do basophils contain
heparin
histamine
bradykinin
what causes basophils to release
released due to binding of IgE
What percent of WBC’s are eosinophils
2%
what do eosinophils defend the body against
worm infections- eg. pinworm
esophils are highly phagocytic for what?
Ag-Ab complex
what differentiates into macrophages in tissues
monocytes
lymphocytes (30%) are what two cells
T cell and B cell
what are mast cells similar to
basophils
what do mast cells mediate
allergic reaction
mast cell degranulation releases?
histamine
bradykinin
heparin
SRS-A slow reacting substances of anaphylaxis
what prevents mast cell degranulation
cromyln sodium (intal) given for exercise induced astham
name the 5 actions of phagocytic cells
margination diapedesis ameboid motion chemotaxis phagocytosis
macrophages are derived from
monocytes
where are macrophages present in
lymph nodes lungs liver (kupffer cells) spleen bone marrow
what system do macrophages make to fight off infection
reticuloendothelial system/monocyte macrophage system
what are the 3 main function providing first line of defense
phagocytosis
antigen presentation
cytokine production
phagocytosis
ingest bacteria, virus other foreign particles by powerful oxidizing agents like
