Immunology

Question 1

HLA class associated with abacavir

Answer 1

HLA-B*57:01

Question 2

HLA associated with carbamazepine (2)

Answer 2

HLA-B15:02 and HLA-A31:01

Question 3

HLA associated with allopurinol

Answer 3

HLA-B*58:01

Question 4

Most common complement deficiency

Answer 4

C2 (then C4 then C3)

Question 5

Pathophys of PNH

Answer 5

Deficiency of membrane bound complement regulatory proteins CD59 or CD55 (decay accelerating factor) and clonal expansion of mutant PIG-A HSCTs)

Question 6

Strong linkage disequilibrium between which MHCs

Answer 6

HLA-B and C

Question 7

What HLA are the following associated with:

1. 21-OH def
2. Haemachromatosis
3. Coeliac

Answer 7

1. HLA-B47
2. HLA-A3/HFE
3. HLA-DQ2 and DQ8

Question 8

What do CD4 cells recognize

Answer 8

MHC class II

Question 9

In which diseases is there a defect in number or function of Treg cells

Answer 9

T1DM
MS
SLE
MG
RA

Question 10

Lack of T cell results in what main disease processes

Answer 10

Intercellular organism infection - fungi, viruses CMV, listeria, protozoa

Question 11

Mucosal candida is a problem of what cell

Answer 11

Th17

Question 12

What initiates MaC

Answer 12

C5 convertase at end of alternate pathway

Question 13

Where is CRP involved in the complement pathway

Answer 13

Classical pathway - it can activate C1q to start classical

Question 14

Mediators and regulators of innate immunity?

Answer 14

IL-1, IL-10, IL-12, TNFa, IL-6, IFNa/b, IFNg

Question 15

Mediators and regulators of adaptive immunity?

Answer 15

IL-2, IL-4, IL-5, TGF-B