Haematology

Question 1

Chromosomal change in:

1) follicular lymphoma
2) Burkitt’s
3) mantle cell lymphoma

Answer 1

1) t(14;18) -> BCL2
2) t(8;14)
3) t(11;14)

Question 2

What is the chromosomal abnormality in double hit lymphoma?

Answer 2

Myc + BCL2/BCL6

Question 3

Eosin-5-maleimide is used in the diagnosis of which condition?

Answer 3

Hereditary spherocytosis - low E5M

Question 4

Hereditary spherocytosis is a defect in what?

Answer 4

Molecular defects in genes encoding for RBC membrane cytoskeleton proteins 4.1, spectrin, ankyrin and other horizontal proteins