Immunology Flashcards
Are NK cells part of the innate or adaptive immune system?
Innate
What antibody is rapidly produced by memory B cells at re-exposure to a microbe after vaccination?
IgG
Are biological drugs metabolised by the liver and excreted by the kidney?
No - you can use them even if your liver and kidney are shot
What part of the immune system are biological drugs part of?
Passive immunity - you are just being given the antibody (same as breastfeeding) so it’s passive
What is the best antibody test for lupus?
Anti-dsDNA
What is the best antibody test for Siogrens syndrome?
Anti-Ro and anti-La
What is the best antibody test for diffuse cutaneous systemic sclerosis?
Anti –topoisomerase or anti SCL-70
What is the best antibody test for limited systemic sclerosis?
Anti-centromere antibody
What are the antibody tests for anti-phospholipid syndrome
- IgM or IgG anticardiolipin antibodies
- Lupus anticoagulant
- IgM or IgG beta 2 glycoprotein
What are the antibody tests for rheumatoid arthritis?
- Rheumatoid factor (Rheumatoid IgM)
- Anti-CCP antibodies
What is the antibody test for mixed connective tissue disease?
Anti RNP antibody
What are the antibody tests for polymyositis and dermatomyositis?
ANA and anti-jo
What type of ANCA is found in granulomatosis with polyangiitis (GPA/Wegener’s)?
cANCA
What type of ANCA is found in eosinophilic granulomatosis with polyangiitis (EGPA)/Churg-Strauss
pANCA
Is methotrexate immunosurpressive?
No, it’s anti-inflammatory (good to use in if patients have history of cancer)
What are the antibodies seen in myesthenia gravis
Anti-ach receptor antibody
What kind of infections tend to happen in people with primary IgA deficiency
Respiratory and GI infections
Do primary immunodeficinecies always present as children?
No - most present in infants but the milder types can present in adulthood
What is one of the biggest contraindications for methotrexate
Liver disease
Can you develop antibodies against biological drugs
Yes
What disease do you have to worry about reactivating while using TNF drugs
TB
