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Transition Block > Immunology > Flashcards

Immunology Flashcards

1
Q

Are NK cells part of the innate or adaptive immune system?

A

Innate

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2
Q

What antibody is rapidly produced by memory B cells at re-exposure to a microbe after vaccination?

A

IgG

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3
Q

Are biological drugs metabolised by the liver and excreted by the kidney?

A

No - you can use them even if your liver and kidney are shot

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4
Q

What part of the immune system are biological drugs part of?

A

Passive immunity - you are just being given the antibody (same as breastfeeding) so it’s passive

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5
Q

What is the best antibody test for lupus?

A

Anti-dsDNA

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6
Q

What is the best antibody test for Siogrens syndrome?

A

Anti-Ro and anti-La

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7
Q

What is the best antibody test for diffuse cutaneous systemic sclerosis?

A

Anti –topoisomerase or anti SCL-70

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8
Q

What is the best antibody test for limited systemic sclerosis?

A

Anti-centromere antibody

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9
Q

What are the antibody tests for anti-phospholipid syndrome

A
  • IgM or IgG anticardiolipin antibodies
  • Lupus anticoagulant
  • IgM or IgG beta 2 glycoprotein
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10
Q

What are the antibody tests for rheumatoid arthritis?

A
  • Rheumatoid factor (Rheumatoid IgM)

- Anti-CCP antibodies

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11
Q

What is the antibody test for mixed connective tissue disease?

A

Anti RNP antibody

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12
Q

What are the antibody tests for polymyositis and dermatomyositis?

A

ANA and anti-jo

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13
Q

What type of ANCA is found in granulomatosis with polyangiitis (GPA/Wegener’s)?

A

cANCA

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14
Q

What type of ANCA is found in eosinophilic granulomatosis with polyangiitis (EGPA)/Churg-Strauss

A

pANCA

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15
Q

Is methotrexate immunosurpressive?

A

No, it’s anti-inflammatory (good to use in if patients have history of cancer)

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16
Q

What are the antibodies seen in myesthenia gravis

A

Anti-ach receptor antibody

17
Q

What kind of infections tend to happen in people with primary IgA deficiency

A

Respiratory and GI infections

18
Q

Do primary immunodeficinecies always present as children?

A

No - most present in infants but the milder types can present in adulthood

19
Q

What is one of the biggest contraindications for methotrexate

A

Liver disease

20
Q

Can you develop antibodies against biological drugs

A

Yes

21
Q

What disease do you have to worry about reactivating while using TNF drugs

A

TB

Transition Block (9 decks)

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