Immunology

Question 1

MOA of adrenaline

Answer 1

a1 and B2 adrenoceptor agonists
a1 - reverses peripheral vasodilation and oedema
b2 - dilates airways, increased force of myocardium contraction, decrease histamine, lwukotrienes from mast cell

Question 2

MOA of antihistamine and when are they not effective

Answer 2

competitive antagonism of histamine receptors - esp H1
not effective in bronchial asthma as leukotrienes and bradykinin also have a role
end in -ine eg loratidine, promethazine

Question 3

example of mast cell stabiliser and MOA

Answer 3

sodium cromoglycate

prevents mast cell release of histamine

Question 4

example of leukotrine receptor antagonist

Answer 4

montelukast

Question 5

what are monoclonal AB specific for

Answer 5

block AB specific for either teh Fc region of IgE AB or IGE binding site on FCER1 eg omalizumab

Question 6

in penicillin allergy what AB can you give

Answer 6

gent, azith, metronidazole, ciprofloxacin

Question 7

what is polyarteritis nordosa driven by

Answer 7

Hep B viral surface antigens

Question 8

what is henoch schonlein purpura driven by

Answer 8

IgA

Question 9

c-ANCA vasculitis

Answer 9

GPA

Question 10

p-ANCA

Answer 10

MPA and EGPA

Question 11

goodpastures specific AB

Answer 11

anti-golmerular basement membrane AB