Immunology Flashcards
eosiniphils attack parasites with the help of IgE through what mechanism of action?
Antibody Depentent Cell-mediated Cytotoxicity (ADCC)
Eosinophils are coated with IgE which bind to surface antigens on parasites. Once activated, they degranulate their contents destroying the parasite
What is the function of IL-2?
Can IL-2 be used as a chemotherapy agent?
Yes!
It activates NK cells, which can help destroy the tumor cells
In a hyperacute transplant rejection, how long is onset? what causes it? What type of hypersensitivity reaction is it?
onset is within minutes
pre-existing recipient antibodies react to donor antigen (type II hypersensitivity reaction)
In an acute transplant rejection, how long is onset? What causes it? what type of hypersensitivity reaction is it?
weeks to months
T cells activated against donor MHCs
Type IV
In a chronic transplant rejection, how long is onset? What causes it? What type of hypersensitivity reaction?
months to years
CD4+ T cells respond to recipient APCs presenting peptides
type II and IV
in graft versus host disease, how long is onset? What causes it? What type of hypersensitivity reaction is it?
onset varies
T cells reject host cells with “foreign proteins” –> organ dysfucntion
type IV
What is the differnce between humoral and cellular immunity?
humoral = (humors: fluids) immunty that is mediated by macromolecules found within the body fluids (antibodies)
Cellular = immune process that involves the activation of phagocytes, antigen-sensitized cytotoxic T cells and the release of cytokines and chemokines in response to antigen
HLAs with 1 letter are associated with what MHC class? HLAs with 2 letters are associated with what MHC class?
HLAs with one letter = MHC I
HLAs with two letters = MHC II
define atopy
syndrome characterized by a tendency to be hyperallogenic
What antibodies are associated with polymyositis?
anti-Histidyl-tRNA synthetase (Jo’s antibodies)
