Immunology Flashcards
Which cells express CD3?
T-Cells
Which cells express CD19?
B-Cells
Which cells express CD4?
Helper T-Cells
Which cells express CD8?
Killer T-Cells
Which cells express TLR4?
Macrophages
Which cell is involved in cellular response to intracellular pathogens and type IV hypersensitivty reactions?
TH1
Which cell releases IL-4, IL-5, and IL-13 and is implicated in response to allergens and helminths?
TH2
Which cell type destroys foreign substances via osmotic lysis, secretion of TNF, or induction of apoptosis?
a) cytotoxic T cells
b) NK Cells
c) neutrophils
d) macrophages
a) cytotoxic T cells
NK cells bind antibody coated cells and release perforin or induce apoptosis in Fas-expressing cells.
Neutrophils phagocytose antigens or release lysosomal enzymes or proteolytic enzymes (collagenase, elastase, cathepsin B)
Which cells express CD56 and CD 161?
NK cells
What is the result of activating the following histamine receptor?
A) H1
B) H2
A) smooth muscle contraction, vasodilation, increased vascular permeability, and stimulation of nasal mucous glands
B) enhanced gastric secretion, mucus secretion, and leukocyte chemotaxis
Leukotrienes are formed from ….
arachidonic acid via the lipoxygenase pathway
LTB4 is a chemoattractant for neutrophils
LTC4/D4/E4 trigger more powerful allergic responses than histamines
Prostaglandins & thromboxanes are formed from….
arachidonoic acid via the cyclooxygenase pathway
The classical complement pathway is activated by
IgG and IgM antigen-antibody complexes
The alternative complement pathway is activated by
LPS, trypsin-like molecules, aggregated IgA and IgG, and cobra venom
Which cytokines are involved in inflammation and mediate natural immunity?
IL-1, IL-6, IL-8, TNF and IFN-γ
