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Derm Mine > Immunology > Flashcards

Immunology Flashcards

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Dermatology Board Prep flashcards
1
Q

What are the functions of the keratin layer?

A

Physical barrier

Pathogen detection

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2
Q

Which 3 structural proteins in the keratin layer help maintain its integrity?

A

Filaggrin
Involucrin
Keratin

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3
Q

Which 2 factors can activate antigen detection in keratinocytes?

A

UV light

Allergens

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4
Q

Which proteins that are deadly to pathogens are formed by keratinocytes?

A

Anti-microbial peptides (AMPs)

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5
Q

Which immunological chemicals are produced by keratinocytes?

A

Cytokines

Chemokines

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6
Q

What is the skin’s main resident immune cell?

A

Langerhans cell

- type of dendritic cell in epidermis

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7
Q

Give 4 features of the Langerhans cell

A
  • antigen-presenting cell
  • contain Birbeck granules
  • act as sentinels
  • help activate T cells
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8
Q

Which type of T cell is mainly found in the epidermis?

A

CD8+

cytotoxic cells

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9
Q

Which type of T cell is mainly found in the dermis?

A

Mainly CD4+

T helper cells

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10
Q

Which specific CD4+ TH cell is associated with psoriasis?

A

TH1

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11
Q

Which specific CD4+ TH cell is associated with atopic dermatitis?

A

TH2

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12
Q

Which specific CD4+ TH cell is associated with BOTH psoriasis and atopic dermatitis?

A

TH17

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13
Q

What types of dendritic cells (DC) are present in the dermis? (2)
What do they secrete? (2)

A

Dermal DC: secrete cyto/chemokines

Plasmacytoid DC: produce IFNα

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14
Q

What type of skin are plasmatoid dendritic cells found in?

A

Diseased skin

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15
Q

Which 3 other immunological cell types are found in the dermis?

A

Macrophages
Neutrophils
Mast cells (esp in barriers)

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16
Q

What are 4 pre-formed immunity mediators in mast cells?

A

Tryptase
TNF
Histamine
Chymase

17
Q

Which gene contains the Major Histocompatibility Complex genes?

A

Chromosome 6

18
Q

Give 3 features of MHC Class I gene proteins

A

Found on almost all cells
Present Ag to cytotoxic T cells
Present endogenous Ag

19
Q

Give 3 features of MHC Class II gene proteins

A

Found on APCs (macrophages, B cells)
Present to Thelper cells
Present exogenous Ag

20
Q

What are the main functions of MHC proteins?

A

Recognise self and non-self

- important in transplants

21
Q

Which cells are most implicated in the immunopathogenesis of psoriasis?

A

T cells

22
Q

Mutations in which gene are associated with severe/early onset Atopic Eczema?

A

Filaggrin

23
Q

Which 3 skin conditions are thought to be auto-immune mediated?

A

Psoriasis
Vitiligo
Systemic lupus erythematosus

Derm Mine (7 decks)

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