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Anything under the sun > immunology > Flashcards

immunology Flashcards

1
Q

site of B cell localization and proliferation

A

follicle

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2
Q

mechanisms of antigen inactivation

A

agglutination
opsonization
neutralization
complemen activation

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3
Q

cytokines causing inflammation

A

TNF, IL-1

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4
Q

cytokines for resistance to viral infection

A

IFN a, B

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5
Q

activates macrophages

A

IFN- y

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6
Q

stimulates INF-y production by NK and T cells

A

IL-12

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7
Q

proliferation of NK cells

A

IL-15

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8
Q

MAC complex

A

C5a - C9

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9
Q

small foreign molecule that is not antigenic

A

hapten

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10
Q

proteins that recognize and bind to a particular antigen with very high specificity

A

antibodies

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11
Q

disease due to mutation in superoxide dismutase 1 on chromosome 21

A

Lou-Gehrigs disease/ALS/Charcot disease

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12
Q

most frequent SCID phenotype

A

X-linked (Cytokine Signaling Deficiency)

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13
Q

MC immunodeficiency worldwide

A

isolated IgA

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14
Q

patients with CGD are prone to infections from what organisms

A

catalase positive

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15
Q

what are the catalase positive microorganisms

A 
Chromobacterium violaceum
Aspergillus spp
Burkholderia cepacia
S. aureus
Serratia marcescens
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16
Q

HLA A3 is associated with

A

hemochromatosis

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17
Q

HLA B27 is associated with

A

Psoriatic arthritis
Ankylosing spondylitis
arthritis of Inflammatory Bowel Disease
Reactive arthritis (formerly Reiter syndrome)

PAIR also known as seronegative arthropathies

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18
Q

HLA DQ2/DQ8

A

celiac disease

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19
Q

HLA DR2

A

Multiple sclerosis
hay fever
SLE
goodpasture

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20
Q

HLA DR3

A

DM Type 1

graves

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21
Q

HLA DR4

A

rheumatoid arthritis

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22
Q

HLA DR5

A

pernicious anemia

hashimoto thyroiditis

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23
Q

autosomal recessive condition characterized by defective fusion of phagosomes and lysosomes, resulting in a defective phagocytes function and susceptibility to infections

A

Chediak Higashi syndrome

24
Q

MC complement protein deficiency

A

C2

25
Q

deficiency in C1q, C2 and C4 will lead to

A

SLE like autoimmune disease

26
Q

C3 deficiency will lead to

A

infection with pyogenic bacteria

27
Q

deficiency of the terminal components

A

recurrent Neisserial infections

28
Q

deficiency in NADPH oxidase

A

chronic granulomatous disease

29
Q

anti inflammatory cytokines

A

TGF-B, IL-10

30
Q

cell surface markers of regulatory T cells

A

CD3
CD4
CD25
FOXP3

31
Q

xerostomia, keratoconjunctivitis sicca, rheumatoid arthritis

A

sjogren syndrome

32
Q

are yellowish, cotton wool like fundal lesions

A

cytoid bodies (SLE)

33
Q

Anti-centromere antibody is associated with

A

CREST syndrome

34
Q

double stranded DNA, Anti smith antibodies

A

SLE

35
Q

this disease is characterized by chronic inflammatory proccess esp. the proximal muscles of extremities

A

polymyositis

36
Q

_________ is characterizee by specific ANAs (high titer anti-nRNP and an immunofluroescent speckled appearance on morphologic ANA analysis)

A

Mixed connective tissue disease

37
Q

consists of a group of inherited diseases that are characterized by severely impaired neutrophil counts [

A

severe congential neutropenia

-MC: autosomal dominant

38
Q

Hallmark of severe congenital neutropenia

A

absence of pus

39
Q

are associated with a block in granulopoeisis at the promyelocytic stage

A

severe congenital neutropenia

40
Q

Deficiencies of the innate immune system associated with impaired production of phagocytic cells

A

severe congential neutropenia

asplenia

41
Q

Deficiency of the innate immune system associated with impaired adhesion of phagocytic cells

A

leukocyte adhesion deficiency

42
Q

Deficiencies of the adaptive immune system associated with impaired development of T cells

A

SCIDs

DiGeorge

43
Q

Deficiencies of the adaptive immune system associated with impaired survival, migration and function of T cells

A 
SCID
Hyper-IgE
CD40 ligand deficiency
wiskott aldrich
ataxia telangiectasia
44
Q

Deficiencies of the adaptive immune system associated with impaired development of B cells

A

XL and AR agammaglobulinemia

45
Q

Deficiencies of the adaptive immune system associated with impaired function of B cells

A

Hyper IgM
ALPS (autoimmune lymphoproliferation syndrome)
IgA deficiency

46
Q

Test used in CGD

A

nitroblue tetrazolium dye

47
Q

is a disorder characterized by asplenia, malformations of the heart and abnormal arrangement of internal organs of the chest and abdomen

A

Ivemark syndrome

48
Q

disease characterized by impaired IFN-y dependent macrophage activation

A

Mendelian susceptibility to mycobacepterial disease (MSMD)

49
Q

Hallmark of MSMD

A

specific and narrow vulnerability to TB and nonTB mycobacteria

50
Q

form of SCID thatis characterized by severe neutopenia and sensorineural deafness

A

reticular dysgenesis

51
Q

CHD7 deficiency

A

CHARGE syndrome

52
Q

early onset erythrodermia, alopecia, hepatosplenomegaly, failure to thrive

A

Omenn syndrome

53
Q

characterized by almost complete absence of CD8+ T cells

A

Zeta associated protien 70 deficiency (ZAP70)

54
Q

low CD8, COPD, systemic vasculitis

A

HLA class I deficiency

55
Q

Hallmark of ataxia telangiectasia

A

telangiectasia

cerebellar ataxia

56
Q

________ is due to nibrin deficiency characterized by microcephaly and bird like face

A

Nijmegen breakage syndrome

57
Q

is due to a mutation in dyskerin characterized by absence of B and NK lymphocytes.
microcephaly, bone marrow failur, in utero growth retardation, G.I diseases

A

Hoyeraal Hreidarsson syndrome (dyskeratosis congenita)

Anything under the sun (6 decks)

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