immunology

Question 1

site of B cell localization and proliferation

Answer 1

follicle

Question 2

mechanisms of antigen inactivation

Answer 2

agglutination
opsonization
neutralization
complemen activation

Question 3

cytokines causing inflammation

Answer 3

TNF, IL-1

Question 4

cytokines for resistance to viral infection

Answer 4

IFN a, B

Question 5

activates macrophages

Answer 5

IFN- y

Question 6

stimulates INF-y production by NK and T cells

Answer 6

IL-12

Question 7

proliferation of NK cells

Answer 7

IL-15

Question 8

MAC complex

Answer 8

C5a - C9

Question 9

small foreign molecule that is not antigenic

Answer 9

hapten

Question 10

proteins that recognize and bind to a particular antigen with very high specificity

Answer 10

antibodies

Question 11

disease due to mutation in superoxide dismutase 1 on chromosome 21

Answer 11

Lou-Gehrigs disease/ALS/Charcot disease

Question 12

most frequent SCID phenotype

Answer 12

X-linked (Cytokine Signaling Deficiency)

Question 13

MC immunodeficiency worldwide

Answer 13

isolated IgA

Question 14

patients with CGD are prone to infections from what organisms

Answer 14

catalase positive

Question 15

what are the catalase positive microorganisms

Answer 15

Chromobacterium violaceum
Aspergillus spp
Burkholderia cepacia
S. aureus
Serratia marcescens

Question 16

HLA A3 is associated with

Answer 16

hemochromatosis

Question 17

HLA B27 is associated with

Answer 17

Psoriatic arthritis
Ankylosing spondylitis
arthritis of Inflammatory Bowel Disease
Reactive arthritis (formerly Reiter syndrome)

PAIR also known as seronegative arthropathies

Question 18

HLA DQ2/DQ8

Answer 18

celiac disease

Question 19

HLA DR2

Answer 19

Multiple sclerosis
hay fever
SLE
goodpasture

Question 20

HLA DR3

Answer 20

DM Type 1

graves

Question 21

HLA DR4

Answer 21

rheumatoid arthritis

Question 22

HLA DR5

Answer 22

pernicious anemia

hashimoto thyroiditis

Question 23

autosomal recessive condition characterized by defective fusion of phagosomes and lysosomes, resulting in a defective phagocytes function and susceptibility to infections

Answer 23

Chediak Higashi syndrome

Question 24

MC complement protein deficiency

Answer 24

C2

Question 25

deficiency in C1q, C2 and C4 will lead to

Answer 25

SLE like autoimmune disease

Question 26

C3 deficiency will lead to

Answer 26

infection with pyogenic bacteria

Question 27

deficiency of the terminal components

Answer 27

recurrent Neisserial infections

Question 28

deficiency in NADPH oxidase

Answer 28

chronic granulomatous disease

Question 29

anti inflammatory cytokines

Answer 29

TGF-B, IL-10

Question 30

cell surface markers of regulatory T cells

Answer 30

CD3 CD4 CD25 FOXP3

Question 31

xerostomia, keratoconjunctivitis sicca, rheumatoid arthritis

Answer 31

sjogren syndrome

Question 32

are yellowish, cotton wool like fundal lesions

Answer 32

cytoid bodies (SLE)

Question 33

Anti-centromere antibody is associated with

Answer 33

CREST syndrome

Question 34

double stranded DNA, Anti smith antibodies

Answer 34

SLE

Question 35

this disease is characterized by chronic inflammatory proccess esp. the proximal muscles of extremities

Answer 35

polymyositis

Question 36

_________ is characterizee by specific ANAs (high titer anti-nRNP and an immunofluroescent speckled appearance on morphologic ANA analysis)

Answer 36

Mixed connective tissue disease

Question 37

consists of a group of inherited diseases that are characterized by severely impaired neutrophil counts [

Answer 37

severe congential neutropenia | -MC: autosomal dominant

Question 38

Hallmark of severe congenital neutropenia

Answer 38

absence of pus

Question 39

are associated with a block in granulopoeisis at the promyelocytic stage

Answer 39

severe congenital neutropenia

Question 40

Deficiencies of the innate immune system associated with impaired production of phagocytic cells

Answer 40

severe congential neutropenia | asplenia

Question 41

Deficiency of the innate immune system associated with impaired adhesion of phagocytic cells

Answer 41

leukocyte adhesion deficiency

Question 42

Deficiencies of the adaptive immune system associated with impaired development of T cells

Answer 42

SCIDs | DiGeorge

Question 43

Deficiencies of the adaptive immune system associated with impaired survival, migration and function of T cells

Answer 43

``` SCID Hyper-IgE CD40 ligand deficiency wiskott aldrich ataxia telangiectasia ```

Question 44

Deficiencies of the adaptive immune system associated with impaired development of B cells

Answer 44

XL and AR agammaglobulinemia

Question 45

Deficiencies of the adaptive immune system associated with impaired function of B cells

Answer 45

Hyper IgM ALPS (autoimmune lymphoproliferation syndrome) IgA deficiency

Question 46

Test used in CGD

Answer 46

nitroblue tetrazolium dye

Question 47

is a disorder characterized by asplenia, malformations of the heart and abnormal arrangement of internal organs of the chest and abdomen

Answer 47

Ivemark syndrome

Question 48

disease characterized by impaired IFN-y dependent macrophage activation

Answer 48

Mendelian susceptibility to mycobacepterial disease (MSMD)

Question 49

Hallmark of MSMD

Answer 49

specific and narrow vulnerability to TB and nonTB mycobacteria

Question 50

form of SCID thatis characterized by severe neutopenia and sensorineural deafness

Answer 50

reticular dysgenesis

Question 51

CHD7 deficiency

Answer 51

CHARGE syndrome

Question 52

early onset erythrodermia, alopecia, hepatosplenomegaly, failure to thrive

Answer 52

Omenn syndrome

Question 53

characterized by almost complete absence of CD8+ T cells

Answer 53

Zeta associated protien 70 deficiency (ZAP70)

Question 54

low CD8, COPD, systemic vasculitis

Answer 54

HLA class I deficiency

Question 55

Hallmark of ataxia telangiectasia

Answer 55

telangiectasia | cerebellar ataxia

Question 56

________ is due to nibrin deficiency characterized by microcephaly and bird like face

Answer 56

Nijmegen breakage syndrome

Question 57

is due to a mutation in dyskerin characterized by absence of B and NK lymphocytes. microcephaly, bone marrow failur, in utero growth retardation, G.I diseases

Answer 57

Hoyeraal Hreidarsson syndrome (dyskeratosis congenita)