Immunology

Question 1

What are the receptor and ligand for APC and T cells?

Answer 1

CD28 on T cells, B7 on APC

Question 2

What are the receptor and ligand for B cells and T cells?

Answer 2

CD40L on T cells, CD40 receptor on B cells

Question 3

What is IL-2’s receptor?

Answer 3

CD25

Question 4

What is the most important inflammatory factor in the body?

Answer 4

TNF

Question 5

What is the function of TNF? alpha, beta, gamma?

Answer 5

antiviral activity, tumoricidal effect
alpha and beta made by macrophages
gamma made by T cells and stimulates macrophages (activates them)

Question 6

What is IL2 made by? What does it stimulate?

Answer 6

made by T cells, stimulates B cells and macrophages

Question 7

What is IL-4’s function?

Answer 7

Bcell growth factor (stimulation of B cell by T cell)

Tcell growth factor and regulator of T cell function

Question 8

What type of Tcell response is IL-10 produced by?

Answer 8

TH2 response, may suppress TH1 cytokines

Question 9

What interleukin stimulates TH1 response?

Answer 9

IL-12

Question 10

What is the primary mediator of septic shock in humans?

Answer 10

TNFalpha, responsible for vascular damage and fever

Question 11

Describe TH1 response

Answer 11

activate CMI by producing IL-2, IFN gamma, TNFbeta

promoted by IL-12

Question 12

Describe TH2 response

Answer 12

active B cells by producing IL-4, IL-5, IL-6

Question 13

What is IL-5’s function?

Answer 13

B cell growth factor and differentiation factor