Immunology Flashcards

1
Q

Define immune system

A

A system of cells and tissues that attacks, recognises, and destroys foreign substances that endangers one’s health

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2
Q

Why are humans described as super organisms

A

They have an internal ecosystem of diverse symbiotic microbiota and viruses

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3
Q

Pathogens

A

Microorganisms external to the human host that produce diseases

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4
Q

Pathobionts

A

Pathogens that stay within the host microbiome

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5
Q

Example of pathogens
[6]

A

Helminths
Fungi
Protozoa
Bacteria
Viruses
Prions

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6
Q

2 categories of pathogens

A

Extracellular
Intracellular

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7
Q

Extracellular pathogens

A

Microorganisms that stay in tissue and don’t need to enter host cell to replicate

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8
Q

Intracellular pathogens

A

Microorganisms that need to enter host cell to be replicated

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9
Q

2 types of intracellular pathogens

A

Obligate
Facultative

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10
Q

Obligate

A

Stay inside host cell and can’t replicate outside of host cell

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11
Q

Facultative

A

Live in host cell
Can replicate without host cell

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12
Q

Pathogenicity

A
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13
Q

2 types of immune response

A

Innate
Adaptive

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14
Q

Innate immune system

A

The initial response to pathogens

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15
Q

Adaptive immune response

A

After the innate response is unable to block the spread

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16
Q

3 components of an effective immune system
RDC

A

Recognition system
Disposal system
Communication system

17
Q

Recognition system

A

Helps identify the presence of invader

18
Q

Importance of a Disposal system

A

To kill or eliminate threat

19
Q

Importance of a communication system

A

Return body to previous conditions

20
Q

Compare the evolutionary origins of innate and adaptive immunity

A

Innate - invertebrates and vertebrates [present before birth]
Vertebrates - vertebrates

21
Q

Compare the blood cell type of innate and adaptive immunity

A

Innate - phagocytes
Adaptive - lymphocytes

22
Q

Compare the specificity of recognition of innate and adaptive immunity

A

Innate - non specific
Adaptive - high

23
Q

Compare the speed of action of innate and adaptive immunity

A

Innate - rapid
Adaptive - slow

24
Q

Does innate immunity develop memory Cells

25
Does adaptive immunity develop memory Cells
YES
26
Types of innate immunity [2]
Non induced Induced
27
Non induced innate mechanisms
Mediated by physical barriers
28
Induced innate mechanism
Mediated by complement and leukocytes
29
2 components of pathogen recognition
1st element - in pathogen 2nd element - in host cell
30
PAMPs
Molecular configuration in pathogens
31
PRMs
Host structure that recognises PAMPs
32
PRRs
PRMs found in leukocytes or in cytoplasm
33
Order of immune system
Barrier Innate Adaptive
34
Example of Barrier immunity
Respiratory epithelium GI epithelium Nose Pharynx
35
Example of cells innate immunity
Neutrophils Mast cells Monocytes Macrophages