Cardiovascular System Flashcards
Cardiovascular diseases
Disease of the heart + blood vessels
Example of things that lead to cardiovascular diseases
Age
Sex
Obesity
Smoking
Family history
High blood pressure
Diabetes
High cholesterol
Types of cardiovascular diseases
Coronary artery disease
Heart failure
Stroke
Chronic kidney disease
Two phases of a heart beat
Systole (pumping)
Diastole (relax)
What is cardiac output
Amount of blood pumped out the heart per minute
Cardiac out equation
CO = HR x SV
What I’d blood pressure
The force of blood pushing against artery walls
Systemic vascular resistance
Resistance in circulatory system used to make blood pressure
When blood vessels constrict. What happens to SVR
Systemic vascular resistance increase
When blood vessels dilate. What happens to SVR
Systemic vascular resistance decrease
How is blood pressure maintained
Using a sphygmomanometer
What two readings does a sphygmomanometer show
Systolic BP
diastolic BP
What is systolic blood pressure
When heart contracts and highest pressure
Diastolic blood pressure
When heart relaxes and lowest pressure
Average systolic BP
120mmHg
Average diastolic BO
80mmHg
What organs control pressure
Kidneys
Heart
Brain.
Arteries
How do kidneys control blood pressure
(RAAS)
Renin. Angiotensin aldosterone system
What happens to blood in the kidneys
filtered to remove water + toxins
What is the nephron made up of
The glomerulus
Bowman’s capsule
Renal tubule
Role of bowman’s capsule
Helps filter blood
What happens to the kidneys when BP drops
Reduce blood flow to kidney
What happens to the renal tubules when BP drops
Reduce filtration
Less sodium delivered
What happens to RAAS when BP drops
it’s activated to increase BP
RAAS
Renin converts angiotensinogen to angiotensin I
angiotensin I - angiotensin II
angiotensin II = makes blood vessel constrict
Adrenal gland release aldosterone
Aldosterone goes back to kidney
What enzyme converts angiotensin | to angiotensin |
ACE
Consequence of hypertension
Stroke
Heart attack
Heart failure
Peripheral vascular disease
Chronic kidney disease
What is classed as hypertension
Systolic bp >140mmHg
Diastolic bp >90mmHg
Cause of heart failure
Diabetes
Hypertension
Myocardial disease
Valvular heart dishes
Ischaemic heart disease
Clinical feature of HF diagnosis
Fluid retention
Shortness of breath
Chest pain
Palpitations
Fainting
Dizziness
Key blood test for HF diagnosis
NT pro BNP
Key imaging test for HF diagnosis
ECG or cardiac MRI
Chronic kidney disease
Reduction in kidney function for >3 months
Cause of chronic kidney disease
Diabetes
hypertension
Genetic disease
Vascular disease
Clinical feature for CKD diagnosis
Fluid retention
Shortness of breath
Weakness
Key test for CKD diagnosis
Measure kidney function
Measure urine protein
Common cause of HF and CKF
Diabetes
Hypertension
Key drugs to treat
Diuretics
ACE inhibitors
Angiotensin receptor blockers
How do ACE inhibitors work
Blocks enzyme ACE from converting angiotensin I to angiotensin II
How do angiotensin receptor blockers work
Block effects of angiotensin II
What vein carries oxygenated blood
Pulmonary vein
What is RAAS
Regulated feedback
Role of aldosterone
Allow salt and water to re absorbed by kidney
Natriuretic meaning
“Make you wee”
What would a patient with heart disease or CKD look like
Fluid in lung
Swollen ankle
Swollen stomach
Congested
Where does loop diuretics work
In the ascending loop
How do loop diuretics work
Block sodium and potassium reabsorption
How does loop diuretic help a patient
How do ace inhibitors lower blood pressure
Stop constriction of arteries
What does the reduction in aldosterone produce cause
Retention of salt and water