Immunology Flashcards
What is this describing:
1. IgG binds to host/foreign antigen
2.patrolling NC cell binds to FC portion of IgG using CD16
3. binding triggers NK cell to release granules containing perforin and granzyme)
4. induce apoptosis
ADCC antibody-dependent cellular toxicity
What produces IL-1 and what are its major effects?
up neutrophil & macrophage migration
up acute phase reactants, fever and shock
What produces IL-2 and what are its major effects?
T cells; T cell activation and proliferation; up NK cell and macrophages; up B cell growth
What produces IL-3 and what are its major effects?
T cells; hematopoeisis
What produces IL-4 and what are its major effects?
TH2 cells; TH2 differentiation; B cell growth; isotype switching to IgE
What produces IL-5 and what are its major effects?
TH2; up differentiation of eosinophils; isotype switching to IgA
What produces IL-6 and what are its major effects?
macrophages: T &B cell growth; osteoclast activity up; acute phase reactants and fever
What produces IL-7 and what are its major effects?
Macrophages and T cells: neutrophil activation and chemotaxis
What produces IL-10 and its major effects?
TH2 cells: DOWN TH1 cell differentiation; DOWN cell mediated immunity and APC activity; up B cell function (T reg.)
What produces IL12 and its major effect?
Macrophages; up TH1 differentiation; up NK cell and CD 8 t cell activity
What produces IFN gamma and its major effect?
TH1 cells and NK cells; up intracellular killing by macrophages; up MHC class 1 and 2 expression; TH1 cell differentiation
What produces TGF beta and its major effect?
most cells; DOWN immune cell function; up matrix synthsis and angiogenesis
What produces GM CSF and its major effect?
Tcells and macrophages; up growth and differentiation of myeloid progenitors
