Immunology Flashcards
B lymphocytes when stimulated by antigen, evolve into_________that secrete antibody
Plasma cells
Which IgG subclasses are most efficient at activating complement?
IgG1 and IgG3
IgG4 does not activate complement
Enhancement media affects agglutination reactions by ____________the zeta potential
Decreasing or reducing
Le a substance is found in the saliva of individuals who are_______
Le a+b substance is found in the saliva of individuals who are_______
Le (a+b-)
Le (a-b+)
True of False: ABO incompatibility between the mother and the fetus protects against sensitization to the D antigen because ABO incompatible fetal red cells are destroyed by maternal ABO antibodies.
True
What is the formula for calculating the number of vials fo RhIG to give when performing a Kleihauer-Betke?
fetal cells/2000 X 5000mL=FMH (mL)
FMH (mL)/30 mL- # vials of RhIG to administer
List five categories of immune hemolytic anemia.
WAIHA
CAD
PCH
Mix-type AIHA
Drug-induced (DIIHA)
What are four types of DIIHA?
Drug-dependent or drug adsorption
Drug-dependent (immune complex type)
Drug-independent (w/ production of autoabs-indistinguishable from WAIHA)
Nonimmunologic + protein adsorption
Autoantibody specificities are often directed against high-prevalence antigens in which blood group systems?
Rh, LW, MNS and DI
Units or vials of RhIG to be administered is calculated by the following formula_________
Vials of RhIG= % fetal cells X 50 divided by 30
% Fetal cells=number of fetal cells per 1000 maternal cells
50=factor to account for average maternal blood volume
30=average quantity of fetal-maternal bleed
PNH patients have absent or decreased expression of _________linked antigens. These patients fail to regulate________ due to the absence of ________ and ___________. These proteins regulate________ and _________ and _______respectively.
GPI
Complement
DAF (CD55) and CD50
C3 & C5 convertases
C5
TTP patients have a deficiency of ___________.
ADAMTS 13
