Hematology Flashcards
_________(HPC) include _______cells, ________cells and _______cells.
Hematopoietic precursor cells (HPC) are stem cells, precursor cells and maturing cells.
Stem cells constitute approx______% of total HPCs.
0.5%
Progenitor cells represent approx _____% of all HPCs.
3%
Maturing cells represent approx _______% of HPCs.
95%
True or False: Cytokines (growth factors, interleukins) regulate differentiation and proliferation of HPCs.
True
LIst five sites where hematopoiesis occurs
- Yolk sac
- Liver
- Spleen
- Bone Marrow
- Thymus
- Lymph nodes
What is the maturation sequence for erythrocytes?
Rubriblast—————-prorubricyte———————-rubricyte——————————metarubricyte———-reticulocyte———-mature erythrocyte
Pronormobalast____Basophilic normoblast____polychromatic normoblast—-orthochromic normoblast—polychromatic erythrocyte——-mature erythrocyte
What is the maturation sequence of granulocytes?
Myeloblast—-promyelocyte——myelocyte——metamylecyte——band neutrophil——segmented neutrophil
(Same for eosinophils and basophils)
What is the maturation sequence for monocytes and/or macrophages?
Monoblast——promonocyte——-monocyte——macrophage
The red cell membrane is composed of ________, ________ and _________.
Proteins (50%)
Phospholipids (40%)
Cholesterol (10%)
The protein matrix of the red cell membrane consists of two types of proteins, ______ and _____.
Integral and peripheral
What is the role of integral proteins on the red cell membrane?
- Expand though the membrane and support active and passive transport of electrolytes
- Position 30 red cell antigens on glycophorin A, B and C
What is the role of peripheral proteins on the red cell membrane?
Located on the internal (cytoplasmic) side of the membrane-manages red cell deformability through spectrin, ankyrin & actin.
The red cell is fully hemoglobinized by which stage in the maturation process?
Reticulocyte (begins at basophilic normoblast stage)
True or False: 2, 3 DPG increases oxygen affinity
False—increases
