Immunology

Question 1

What is the main source of IL-1 and what is its function?

Answer 1

Source: Macrophages

Functions: Acute inflammation, induces fever

Question 2

What is the main source of IL-2 and what is its function?

Answer 2

Th1 cells

Stimulates growth and differentiation of T cell response

Question 3

What is the main source of IL-3 and what is its function?

Answer 3

Source: Activated T helper cells

Functions: Stimulates differentiation and proliferation of myeloid progenitor cells

Question 4

What is the main source of IL-4 and what is its function?

Answer 4

Th2 cells

Stimulates proliferation and differentiation of B cells

Question 5

What is the main source of IL-5 and what is its function?

Answer 5

Th2 cells

Stimulates production of eosinophils

Question 6

What is the main source of IL-6 and what is its function?

Answer 6

Source: Macrophages + Th2 cells

Stimulates differentiation of B cells

Question 7

What is the main source of IL-8 and what is its function?

Answer 7

Source: Macrophages

Function: Neutrophil Chemotaxis

Question 8

What is the main source of IL-10 and what is its function?

Answer 8

Source: Th2 cells

Function:
Inhibits Th1 cytokine production
Also known as ‘human cytokine synthesis inhibitory factor’ + is an anti-inflammatory cytokine

Question 9

What is the main source of IL-12 and what is its function?

Answer 9

Source: Dendritic cells + Macrophages + B cells

Function:
Activates natural killer cells
Stimulates differentiation of naïve T cells into Th1 cells