Immunology Flashcards
Where does papain cleave immunoglobulin?
Above the hinge, resulting in 2 Fab fragments and 1 Fc fragment
Where does pepsin cleave immunoglobulin?
Below the hinge, resulting in 1 Fab(2) fragment and 1 Fc fragment
Which cytokine induce production of IgG1?
IFN-g and IL-4
Which cytokine induce production of IgG2?
IFN-g and TGF-b
Which cytokine induce production of IgG3?
IFN-g
Which cytokine induce production of IgG4?
IL-4 and IL-13
Which cytokine induce production of IgA?
TGF-b and IL-5
Which cytokine induce production of IgM?
None. IgM is produced as primary response prior to class switching.
Which cytokine induce production of IgE
IL-4 and IL-13
What does mutation in IL-12Rb1 associated with
Infection with intracellular bacteria, notably salmonella and atypical mycobacteria
What does IRAK-4 deficiency cause?
susceptibility to pyogenic infections, especially strep. pneumonia
What is the cause of Castleman’s disease?
Hyperproduction of IL-6
What receptors got affected in X-linked SCID?
IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. All contain gc, which is affected in X-linked SCID
What does receptors for IL-3, IL-5 and GM-CSF shares?
Common beta chain
Function of SCF (stem cell factor)
- Act on immature stem cells with c-kit
- Enhances response to other CSFs
- Sustain viability of T cells in the thymus
- Mast cell growth factor
