Immunologic System

Question 1

Common S&S of Dysfunction w/ Immunologic System

Answer 1

1. nail bed changes
2. unusual fatigue
3. Constitutional sympt (fever)
4. generalized wk
5. jnt pain

Question 2

What are 2 Immunodeficiency disorders

Answer 2

1. HIV

2. AIDS

Question 3

What is at risk w/ AIDS & AIDs can lead to?

Answer 3

CT; Kaposi’s sarcoma, lympohma, cough, bruises, mm atrophy & wk

Question 4

Name & Describe the 4 Hypersensitivity disorders

Answer 4

Type I-Anaphylactic- Allergies- Anaphylaxis is life threatening
Type II- Cytolytic/toxic- attack/destroy cells
Type III- Immune Complex- attack/residue cells
Type IV- Cell mediated- antigens form

Question 5

Which Hypersensitivity disorder: SOB, wheezing, stridor, Erythema & Periorbital edema, hives, tachycardia (ie Asthma)

Answer 5

Type I Anaphylactic

Question 6

Which Hypersensitivity disorder: Acute care; tachycardia, HYPOTENTION, headache, back/chest pain, (ie Myasthenia Gravis, Graves Disease/hyperthyroidism)

Answer 6

Type II- Cytolytic/ toxic

Question 7

Which Hypersensitivity disorder: 6-14 days post serum injection, fever, edema, arthralgia (ie RA, Systemic lupus erythematous)

Answer 7

Type III-Imune Complex

Question 8

Which Hypersensitivity disorder: 24-72 hours post exposure- injection or contact itching/erythema, skin lesions (ie MS, transplant rejection)

Answer 8

Type IV-Cell mediated (antigen formes post exposure)

Question 9

3 Neurologic disorders

Answer 9

Myasthenia gravis, Guillain-Barre syndrome, MS

Question 10

Which neurologic disorder: ♀ 20-30; ♂>50; small mm & proximal (difficulty w/ vision, speech, swallowing) ; mm wk, fatiguing wk

Answer 10

Myasthenia Gravis

Question 11

Which neurologic disorder: 1st Bilat LE paresthesias, rapid progressive wk, Fever, Nausea

Answer 11

Guillain-Barre Syndrome

Question 12

Which neurologic disorder: ♀ 20-40, unilat visual impairment, paresthesia, ataxia, fatigue, mm wk, S&S optic neuritis, nystagmus, spasticity, CNS

Answer 12

MS

Question 13

5 Autoimmune disorders

Answer 13

1. fibromyalgia
2. RA
3. SLE
4. Scleroderma
5. Spondyloarthropathy

Question 14

Which Autoimmune disorder: 11/18 tender points, Gender, widespread mm tenderness, fatigue, headache, morning stiffness, Raynauds

Answer 14

Fibromyalgia

Question 15

Which Autoimmune disorder: swelling in 3 or + jnts, stiffness in morning lasting >1 hr, freq the hands, obvious jnt redness & warmth, + serum factor, unexplained wt loss; Symptoms/flareups are >2 wk.

Answer 15

Rheumatoid arthritis

Question 16

Side note: if morning stiffness is <1 hr then it is?

What else gets morning pain?

Answer 16

OA; Spinal conditions

Question 17

Which Autoimmune disorder: ♀, 15-40, AA, Asian, hispanic 2-3x >caucasian, constitutional symptoms, achy jnts, arthritis, butterfly skin rash

Answer 17

Systemic Lupus Erythematosus

Question 18

Which Autoimmune disorder: has raynauds, tight skin, arthralgia, stiffness, GI complains (IBS)

Answer 18

Scleroderma

Question 19

Raynauds accompanies which Autoimmune disorders:

Answer 19

Scleroderma & Fibromyalgia

Question 20

Which Autoimmune disorder: ♂, + HLA-B27, insidious LBP, wt loss, worse in AM

Answer 20

Spondyloarthropathy (6)

1. Ankylosing Spondylitis
2. Reiter’s syndrome/reactive arthritis
3. Psoriatic arthritis
4. Infectious/septic arthritis
5. Lyme disease
6. Bacterial arthritis

Question 21

Which Spondyloarthropathy: SI jnt & lumbar spine, loss of ROM, use of Wright-Schober test

Answer 21

Ankylosing Spondylitis

Question 22

Which Spondyloarthropathy: plantar fascitis/heel pain, abrupt onset, 2-4 wk post STD/gastroenteritis

Answer 22

Reiter’s syndrome/reactive arthritis

Question 23

Which Spondyloarthropathy: nail bed changes, 20-30 yrs psoriasis in hands/feet

Answer 23

Psoriatic arthritis

Question 24

Which Spondyloarthropathy: Risk factor- older, diabetic, immunosuppressed; single jnt affected, fever, ↑WBC

Answer 24

Infectious/septic arthritis

Question 25

Which Spondyloarthropathy: small “Bulls Eye” rash, fever, arthritis occurs later, peripheral neuropathy, older pt rapidly decline.

Answer 25

Lyme disease (by way of tic bite) IMMEDIATE contact to physician

Question 26

Which Spondyloarthropathy: hx of infection, 1 jn, red, swollen, similar to Septic arthritis

Answer 26

Bacterial Arthritis

Question 27

HLA-B27 indicates or R/I

Answer 27

ankylosing spondylitis, reiters/reactive arthritis, Graves disease, RA, MS