Immunologic System Flashcards
Common S&S of Dysfunction w/ Immunologic System
- nail bed changes
- unusual fatigue
- Constitutional sympt (fever)
- generalized wk
- jnt pain
What are 2 Immunodeficiency disorders
- HIV
2. AIDS
What is at risk w/ AIDS & AIDs can lead to?
CT; Kaposi’s sarcoma, lympohma, cough, bruises, mm atrophy & wk
Name & Describe the 4 Hypersensitivity disorders
Type I-Anaphylactic- Allergies- Anaphylaxis is life threatening
Type II- Cytolytic/toxic- attack/destroy cells
Type III- Immune Complex- attack/residue cells
Type IV- Cell mediated- antigens form
Which Hypersensitivity disorder: SOB, wheezing, stridor, Erythema & Periorbital edema, hives, tachycardia (ie Asthma)
Type I Anaphylactic
Which Hypersensitivity disorder: Acute care; tachycardia, HYPOTENTION, headache, back/chest pain, (ie Myasthenia Gravis, Graves Disease/hyperthyroidism)
Type II- Cytolytic/ toxic
Which Hypersensitivity disorder: 6-14 days post serum injection, fever, edema, arthralgia (ie RA, Systemic lupus erythematous)
Type III-Imune Complex
Which Hypersensitivity disorder: 24-72 hours post exposure- injection or contact itching/erythema, skin lesions (ie MS, transplant rejection)
Type IV-Cell mediated (antigen formes post exposure)
3 Neurologic disorders
Myasthenia gravis, Guillain-Barre syndrome, MS
Which neurologic disorder: ♀ 20-30; ♂>50; small mm & proximal (difficulty w/ vision, speech, swallowing) ; mm wk, fatiguing wk
Myasthenia Gravis
Which neurologic disorder: 1st Bilat LE paresthesias, rapid progressive wk, Fever, Nausea
Guillain-Barre Syndrome
Which neurologic disorder: ♀ 20-40, unilat visual impairment, paresthesia, ataxia, fatigue, mm wk, S&S optic neuritis, nystagmus, spasticity, CNS
MS
5 Autoimmune disorders
- fibromyalgia
- RA
- SLE
- Scleroderma
- Spondyloarthropathy
Which Autoimmune disorder: 11/18 tender points, Gender, widespread mm tenderness, fatigue, headache, morning stiffness, Raynauds
Fibromyalgia
Which Autoimmune disorder: swelling in 3 or + jnts, stiffness in morning lasting >1 hr, freq the hands, obvious jnt redness & warmth, + serum factor, unexplained wt loss; Symptoms/flareups are >2 wk.
Rheumatoid arthritis
Side note: if morning stiffness is <1 hr then it is?
What else gets morning pain?
OA; Spinal conditions
Which Autoimmune disorder: ♀, 15-40, AA, Asian, hispanic 2-3x >caucasian, constitutional symptoms, achy jnts, arthritis, butterfly skin rash
Systemic Lupus Erythematosus
Which Autoimmune disorder: has raynauds, tight skin, arthralgia, stiffness, GI complains (IBS)
Scleroderma
Raynauds accompanies which Autoimmune disorders:
Scleroderma & Fibromyalgia
Which Autoimmune disorder: ♂, + HLA-B27, insidious LBP, wt loss, worse in AM
Spondyloarthropathy (6)
- Ankylosing Spondylitis
- Reiter’s syndrome/reactive arthritis
- Psoriatic arthritis
- Infectious/septic arthritis
- Lyme disease
- Bacterial arthritis
Which Spondyloarthropathy: SI jnt & lumbar spine, loss of ROM, use of Wright-Schober test
Ankylosing Spondylitis
Which Spondyloarthropathy: plantar fascitis/heel pain, abrupt onset, 2-4 wk post STD/gastroenteritis
Reiter’s syndrome/reactive arthritis
Which Spondyloarthropathy: nail bed changes, 20-30 yrs psoriasis in hands/feet
Psoriatic arthritis
Which Spondyloarthropathy: Risk factor- older, diabetic, immunosuppressed; single jnt affected, fever, ↑WBC
Infectious/septic arthritis
Which Spondyloarthropathy: small “Bulls Eye” rash, fever, arthritis occurs later, peripheral neuropathy, older pt rapidly decline.
Lyme disease (by way of tic bite) IMMEDIATE contact to physician
Which Spondyloarthropathy: hx of infection, 1 jn, red, swollen, similar to Septic arthritis
Bacterial Arthritis
HLA-B27 indicates or R/I
ankylosing spondylitis, reiters/reactive arthritis, Graves disease, RA, MS
