IMMUNOGLOBULIN

Question 1

An incomplete antigen

Not immunogenic by itself.

When it binds to carrier protein it can elicit immune response.

Most common carrier: Albumin

Answer 1

HAPTEN

Question 2

can induce an immune response

Answer 2

IMMUNOGEN

Question 3

A special class of immunogen that induces hypersensitivity reactions

Answer 3

ALLERGEN

Question 4

Substances that is added to immunogens to induce response

Actions: prolongs the retention time of the immunogen in the body

Increases the effective size of immunogen

Answer 4

ADJUVANTS

Question 5

The strength of the attraction between an epitope and the antigen combining site of the antibody

Simple interaction

Answer 5

AFFINITY

Question 6

Refers to the strength of interaction between complex antigens and antibodies

Complex interaction

Answer 6

AVIDITY

Question 7

Substances, spec. glycoproteins, produced by B lymphocytes or plasma cells in response to antigenic stimulation

Answer 7

ANTIBODIES

Question 8

Heavy chain structure

Answer 8

ISOTYPE

Question 9

Genetically determines differences in the antibodies in individuals

Answer 9

ALLOTYPE

Question 10

Pertains to the variable region of the antibody

Answer 10

IDIOTYPE

Question 11

site for heavy chain synthesis

Answer 11

CHROMOSOME 14

Question 12

FOUND IN CHROMOSOME LINE 2

Answer 12

KAPPA LIGHT CHAIN

Question 13

FOUND IN IN CHROMOSOME 22

Answer 13

LAMBDA LIGHT CHAIN

Question 14

Glycoprotein that is responsible for linking/bridging monomers together

Answer 14

J CHAIN/JOINING CHAIN

Question 15

Binds with compliment protein specifically C1Q – is the recognition site for antibody

Answer 15

CH2

Question 16

Responsible for specificity of the Immunoglobulin

Answer 16

Variable region

Question 17

Responsible for cytotropic reactions involving white blood cells

Links to the receptor on the cell membrane

Answer 17

CH3

Question 18

Flexible region of antibody

Answer 18

HINGE REGION

Question 19

Provides immunity to the new born

Participates in agglutination and precipitation reaction

Acquired passive immunity

21-23 DAYS

Major in secondary Immune response

Answer 19

IgG

Question 20

o 66% of total IgG in the serum

o Has 2 disulfide bonds

Answer 20

IgG1

Question 21

o 23% of total IgG in the serum
o Has 4 disulfide bonds

Answer 21

IgG2

Question 22

o 7% of total IgG in the serum
o Has 15 disulfide bonds

Answer 22

IgG3

Question 23

o 4% of total IgG in the serum
o 2 disulfide bond

Answer 23

IgG4

Question 24

• Primary response antibody
• Biggest immunoglobulin
• Best antibody in terms of fixing compliment

5 DAYS

with J chain

Predominant Ig in First immune response

Answer 24

IgM

Question 25

• Exist as monomer and dimer
• Responsible for mucosal immunity

5-6 DAYS

With J chain

Exist as monomer in serum and dimer in secretion

Answer 25

IgA

Question 26

• Function is still unknown but believes to play a role in immunoregulation
• Found on the surface of B-lymphocytes

2-3 DAYS

B cell activation

heat and acid labile

susceptible to enzyme

Answer 26

IgD

Question 27

• Least abundant Ig in the serum
• Heat-labile antibody, originally known as Reaginic antibody

2-3 DAYS

Answer 27

IgE