IMMUNOGLOBULIN Flashcards
An incomplete antigen
Not immunogenic by itself.
When it binds to carrier protein it can elicit immune response.
Most common carrier: Albumin
HAPTEN
can induce an immune response
IMMUNOGEN
A special class of immunogen that induces hypersensitivity reactions
ALLERGEN
Substances that is added to immunogens to induce response
Actions: prolongs the retention time of the immunogen in the body
Increases the effective size of immunogen
ADJUVANTS
The strength of the attraction between an epitope and the antigen combining site of the antibody
Simple interaction
AFFINITY
Refers to the strength of interaction between complex antigens and antibodies
Complex interaction
AVIDITY
Substances, spec. glycoproteins, produced by B lymphocytes or plasma cells in response to antigenic stimulation
ANTIBODIES
Heavy chain structure
ISOTYPE
Genetically determines differences in the antibodies in individuals
ALLOTYPE
Pertains to the variable region of the antibody
IDIOTYPE
site for heavy chain synthesis
CHROMOSOME 14
FOUND IN CHROMOSOME LINE 2
KAPPA LIGHT CHAIN
FOUND IN IN CHROMOSOME 22
LAMBDA LIGHT CHAIN
Glycoprotein that is responsible for linking/bridging monomers together
J CHAIN/JOINING CHAIN
Binds with compliment protein specifically C1Q – is the recognition site for antibody
CH2
Responsible for specificity of the Immunoglobulin
Variable region
Responsible for cytotropic reactions involving white blood cells
Links to the receptor on the cell membrane
CH3
Flexible region of antibody
HINGE REGION
Provides immunity to the new born
Participates in agglutination and precipitation reaction
Acquired passive immunity
21-23 DAYS
Major in secondary Immune response
IgG
o 66% of total IgG in the serum
o Has 2 disulfide bonds
IgG1
o 23% of total IgG in the serum
o Has 4 disulfide bonds
IgG2
o 7% of total IgG in the serum
o Has 15 disulfide bonds
IgG3
o 4% of total IgG in the serum
o 2 disulfide bond
IgG4
- Primary response antibody
- Biggest immunoglobulin
- Best antibody in terms of fixing compliment
5 DAYS
with J chain
Predominant Ig in First immune response
IgM
- Exist as monomer and dimer
- Responsible for mucosal immunity
5-6 DAYS
With J chain
Exist as monomer in serum and dimer in secretion
IgA
- Function is still unknown but believes to play a role in immunoregulation
- Found on the surface of B-lymphocytes
2-3 DAYS
B cell activation
heat and acid labile
susceptible to enzyme
IgD
- Least abundant Ig in the serum
- Heat-labile antibody, originally known as Reaginic antibody
2-3 DAYS
IgE
