immunodeficiency Flashcards
Deifne primary immunodeficiency
Congenital, resulting from genetic defects, inheritied. The deficiency causes a disease
Define secondary immunodeficiceny
it is acquired - the result of other diseases or conditions ie. HIV
HIV causes the depletion of what cell type
T helper cells
Define humoral immunodeficiency
refers to diseases resulting from impaired antibody production because of either a molecular defect intrinsic to B cells or a failure of interactions between B and T cells
What autoimmune disease may suffer from symptoms such as recurrent sepsis and abcterial infections
lupus
How does hyper IGM syndrome work
There are high levels of IGM antibody and low levels of other antibodies present. This can be due to a fault on T cells or a fault in class switching of antibodies
Where are glucocortocoids produced
adrenal glands
What do glucocortocoids modulate
protein synthesis
What can glucocortocoids be used to treat
hodgkins/non hodgkins lymphoma
How do NSAIDS work
They inhibit the synthesis of prostaglandins by inhibiting cycloxygenases. Prostaglandins induce inflammation ie. PGE1 PGE2 induce inflam. and potentiate effects of histamine and other infla. mediators
What does thromboxane A2 promote
vasocontriction and platelet aggregation
How does aspirin work
modifies and irreversibly inhibits cox pathway
does paracetamol have anti inflammatory effects
no
what can high doses of paracetamol cause
severe hepatoxicity
Desscribe antipeureutic action
fever occurs, causing pyrogens to be released from leucocytes, whcih act directly on thermoregulatory centre in the brains hypathalmus. This causes an increae in body temperature and an increase in prostaglandins
