immunodeficiency Flashcards
primary
congenital
secondary
acquired:
-malnutrition
-Toxic exposure
-infection
defects in innate immunity
Defective:
phagocytosis
bacterial killing
complement deficiency
leukocyte “traffic”
defective phagocytosis
Cant engulf
Chediak-Higashi:
-albinism, cells cant move to phagocytose
defective bacterial killing
Chronic granulomatous disease:
-skin disease is how it shows
primary immunodeficiency: adaptive
B cell defects:
-X-linked agammaglobulinemia
-selective IgA deficiency
Tcell defects:
-Digeorge syndrome
b cell defects:
x-linked agammaglobulinemia
failure of B cell maturation:
no antibody production
in men
B cell defects:
Selective IgA deficiency
effects mucus membranes
respiratory and GI effected
T cell defects:
Digeorge syndrome
effects thymus
failure to produce T cells
Defects which affect both T and B cells
severe combined immunodeficiency (SCID)
tx bone marrow
simian virus
monkey virus
is AIDS a opportunistic infection?
yes
human retrovirus
Starts with RNA goes to DNA (reverse transcriptase)
Creates DNA copy of itself and integrates into host genome
How HIV works
HIV attaches to CD4 molecules
Hides in T cell and is activated when it is
Replication kills the CD4 cell
immune response to HIV
cytotoxic T cells kill HIV-infected cells
B cells produce antibodies
anitbodies bind to circulating virions and activate complement system
anitbodies are not protective
virus remains latent inside lymphocytes
