immunobullous disorders Flashcards
thickening of the keratin layer
hyperkeratosis
thickening of the epidermis
acanthosis
irregular epithelial thickening
papillomatosis
HPV
nuclei in the keratin layer?
parakeratosis
oedema between epidermal cells
spongiosis
the four main classifications of inflammatory skin conditions
spongiotic- intraepidermal oedema (eczema)
psoriasiform - elongation of rete ridges (psoriasis)
lichenoid - basal layer damage(lichen planus/SLE
vesiculobillous -blisters (pemphigoid/pemphigus/dermatitis herpetiformis)
what are some key pathology features of psoriasis?
elongaiton of rete ridges capillary dilation in dermis parakeratosis acanthosis epidermal/demal neutrophil infiltration
what is the auspitz sign?
removal of psoriatic scale causes bleeding due to dermal capillary dilation and elongated dermal papillae
what are the key pathological features of eczema?
spongiotic edema
lymphocyte infiltration
acanthosis
parakeratosis
pathology of lichenoid diseases
irrecular sawtooth acanthosis
damage to basal layer
hypergranulosis
orthohyperkeratosis
what is orthohyperkeratosis
hyperkeratosis with no parakeratosis
what are wickham’s striae
whitish lines visible in the papules of lichen planus and other dermatoses, typically in the oral mucosa
what are the three main immunobullous disorders?
bullous pemphigoid
pemphigus vulgaris
dermatitis herpetiformis
main immunopathology of pemphigus vulgaris
auto IgG against desmogelin-3 resulting in acantholysis
superficial blisters
main immunipathology of bullous pemphigoid
auto IgG agains hemidesmosimes that normally anchor cells to basement membrane
deep blisters
