Immunobiology 2

Question 1

Protein multiunit complex consisting of 2 19s regulatory caps and 1 20s catalytic core. Unaltered and “default” form. Used to cleave peptides into smaller fragments.

Answer 1

Proteasome

Question 2

Variation of the proteasome that has its 20s catalytic core altered to cleave peptides with a higher preference for fragments with hydrophobic domains vs acidic domains.

Alteration is within the 20s catalytic core.

Answer 2

Immunoproteasome

Question 3

Variation of the proteasome that resides in the thymus. Studies show this variation also has its 20s catalytic core altered, however, mice without this variation express lower amounts of naive CD8 T-cells.

Answer 3

Thymoproteasome

Question 4

Two major classes of immuno cell receptors

Answer 4

B-cell receptors and T-cell receptors

Question 5

Two major classes of T-cells

Answer 5

CD8 T-cells
CD4 T-cells

Question 6

CD8 T-cells are also known as

Answer 6

Cytotoxic T-cells

Question 7

CD4 T-cells are also known as

Answer 7

Effector (immuno) CD4 Cells

Question 8

Effector CD8 T-cells primarily do what?

Answer 8

Target (mainly) somatic cells presenting a matching antigen fragment on its MHC I complex.

Question 9

Effector CD4 T-cells do what?

Answer 9

CD4 T-cells recognize cognate antigens on MHC II complexes. Unlike CD8 T-cells, recognition is not limited to somatic cells, but may include recognition of antigens on macrophages like dendrites and other immune cells.

Question 10

Where are newly synthesized MHC I receptors held until they bind with a peptide?

Answer 10

In the endoplasmic reticulum.

Question 11

TAP 1 and TAP 2 form a _________ in the endoplasmic reticulum membrane.

Answer 11

Peptide transporter

Question 12

What does TAP stand for?

Answer 12

Transporters associated with Antigen Processing.

Question 13

True or False: Peptides from the cytosol are transported by TAP into the
endoplasmic reticulum and further processed before binding
to MHC class I molecules.

Answer 13

True

Question 14

If the MHC class I molecules are synthesized in the ER, is it true or false to say that the antigen binding site is not prematurely exposed to the cytosol.

Answer 14

It is true to say. During MHC Class I synthesis in the ER, the two units are folded and assembled properly and the antigen binding site remains outside of the cytosol and within the ER.