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STEP 1 RECALL > Immuno & Micro > Flashcards

Immuno & Micro Flashcards

1
Q

These vessels in the paracortex of lymph nodes allow T and B cells to enter the node from the blood

A

High endothelial venules

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2
Q

This part of the lymph node enlarges in an extreme immune response

A

Paracortex

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3
Q

Lymph from the lateral dorsum of the foot drains first to the _____

A

Popliteal nodes

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4
Q

Drains the right arm and right half of the head

A

Right lymphatic duct

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5
Q

Drains everything except the right arm and right side of the head

A

Thoracic duct

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6
Q

Macrophages in the spleen remove ______________ bacteria

A

Encapsulated bacteria

  • Salmonella
  • S. pneumonia
  • H. Flu
  • N. meningitidis
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7
Q

MHC 1 is found on which cells?

A

All nucleated cells

  • not on RBCs
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8
Q
  • MHC that mediates viral immunity
  • pairs with beta 2 microglobulin
  • binds CD8
A

MHC 1

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9
Q
  • MHC that is expressed only on antigen presenting cells
  • mediates bacterial infections
  • antigens loaded following release of invariant chain in the endosome
  • binds CD4
A

MHC II

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10
Q

Diseases associated with HLA B27

A

“PAIR”

Psoriasis
Ankylosing Spondylitis
Inflammatory bowel dz
Reiter’s syndrome

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11
Q

HLA associated with Hemochromatosis

A

HLA A3

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12
Q

HLA associated with Graves’ disease

A

HLA B8

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13
Q

HLA associated with MS, hay fever, Lupus, & Goodpastures

A

HLA DR2

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14
Q

HLA associated with DM 1

A

HLA DR3

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15
Q

HLA associated with Rheumatoid arthritis and DM 1

A

HLA DR4

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16
Q

HLA associated with pernicious anemia (B12 deficiency caused by autoimmune gastritis) & HASHIMOTOS thyroiditis

17
Q
  • These cells are enhanced by IL-12, IFN-beta & IFN- alpha

- they use perforin & granzyme to kill virally infected and tumor cells

18
Q

Antibodies that can fix complement

A

IgG & IgM

“GM makes classic cars”

  • IgG and IgM start the “classic” complement pathway
19
Q

IgE binds mast cells and basophils & crosslinks free antigen / allergens in type ______________ hypersensitivity rxns

A

Type 1 ( immediate)

20
Q

What activates the alternate complement pathway

A

Microbial surfaces

21
Q

Neutrophils are called by IL-______

A

IL-8 (“clean up on aisle 8”)

22
Q

IL-_____ promotes class switching to IgA

23
Q

Which infections can you give antitoxin to counteract and give passive immunity ?

A

“To Be Healed Rapidly”

Tetanus
Botulinum
Hepatitis B
Rabies

24
Q

IL-12 receptor deficiency causes

A

Decreased Th1 response, disseminated mycobacterial infections

25
Q

Microtubule dysfunction in phagosome- lysosome fusion, recurrent pyogenic infections, partial albinism, peripheral neuropathy

A

Chediak- Higashi syndrome

26
Q

dd

STEP 1 RECALL (12 decks)

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