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Path buzzwords > immuno drugs > Flashcards

immuno drugs Flashcards

1
Q

cyclosporine A
tacrolimus

moa and s/e that effect both

A

calcineurin inhibitor
blocks cytokine transciption, therefore prevenet lymphocyte proliferation and effector function

blocks expression of IL 2

nephrotoxic
htn
neurotoxic

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2
Q

calcinurein inhib that has diabetogenic

A

tacrolimus

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3
Q

calcinuerein inhib that has more dysmorphia and examples

A

cyclosporin

hirsuitism
gingival hypertrophy (like phenytoin as well)
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4
Q

ipilimumab

A

alpha CTLA4 Ab

use for advanced melanoma

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5
Q

alpha CTLA4 ab

A

ipilimumab

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6
Q

alpha PD-1 A

A

pembrolizumab

nivolumab

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7
Q

pembrolizumab

A

alpha PD-1 ab

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8
Q

nivolumab

A

alpha PD-1 ab

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9
Q

cyclophosphamide

use and Moa

A 
alkylates guanine base of DNA
effects B>T
use in many vasculitides?
wegener's SLE
anti cancer
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10
Q 
effect B>T
infertility
haemorrhagic cystitis
malig
PCP
A

cyclophosphamide

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11
Q

cyclophosphamide

side effects

A

infertility (m»F)
hamorrhagic cyctitis
malignancy (bladder, haem, non melanoma skin)
PCP

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12
Q

corticosteroids

use and moa

A

inhibits phosphlipase A1 - reduce prostaglandin

decrease phagocytosis, release of proteolytic enzymes, traffic of phagoctye to inflamme tissue

lymphopenia, block cytopkine gene expression, dec ab prduction, promote apoptosis

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13
Q

azathioprine

A

blocks de novov purine synthesis
pref inhibit T
auto immune
auto inflamm - ibd

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14
Q

azathioprine s/e

A

tmpt

hepatotoxict

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15
Q

mycophenolate mofetil

use and moa

A 
blocks de novo nucletoide synthesis
T>B
transplantation
auto immune
vasculitiis (alter to cyclophospamide)
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16
Q

mycophenolate mofetil

side effects

A

PML from JC virus

herpes reactivation

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17
Q

plasmapheresis - indication

A

Goodpastures
myasthenia gravis
severe vascular regjection

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18
Q

BMT indications

A

SCID
leukcotye adhesion defect
malignancy

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19
Q

Human normal IG replacement therapy - indications

A

Primary ab def
X linked agammaglob (Brutons, BTK gene)
X linked hyper IgM syndrome (CD40L on T)
CVID (epitaxis, lung, GI prob, MHC III? i think, normal IgM with low others)

Secondary
Haem malignancies like
CLL
MM
post BMT
passive immunisations
CMV
VZIG
rabies
HBV IG
tetanus
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20
Q 
recombinant cytokines
indications for
1. IFN alpha
2. beta
3. gamma
A

alpha
HCV, HBV, HHV8, hairy cell, CML, MM

beta
RRMS

gamma
CGD

21
Q

JAK inhibitora

A

tofacitinib

22
Q

tofacitnib

A

JAK inhibitor

23
Q

PDE4 inhibitor

A

apremilast

but also effects PKA pathway

24
Q

apreimilast

A

PDE4 inhibitor

but also effects PKA pathway

25
Q

Anti-thymocyte globulin (take IV)

A

allograft regjection (renal, heart)
from rabbit
ab are anything t cell

26
Q

basiliximab

daclizumab

A

ab specific for CD25
anti IL2 R

prophylaxis of allograft rejection
IV before and after transplant surgery (espesh kidney transplants)

stop t cell prolif

27
Q

anti IL2 R

A

basilximab
daclizumab
ab specific for CD25

28
Q

abatacept

A

CTLA4-Ig fusion protein

RA

reduces T cell activation

29
Q

CTLA4-Ig fusion protein

RA

A

Abatacept

30
Q

which cell suface molecules you DON’T use and why

A

TGN1412 (anti CD 28)
cytokine storm

efalizumab (anti LFA1)
fatal cases of PML (prog multifocal leukoenceph)

31
Q

Rituximab

A

CD20 specific

lymphoma
RA
SLE

depletes mature B cells - leaves plasma cells

consider Hep B core Ab+ if using this

32
Q

anti CD20 and indications

A

RItuximab
lymphoma
RA
sle

33
Q

Natalizumab

A

alpha4 integrin

RRMS
(Crohn’s)

inhibits T cell migration

34
Q

Tocilizumab

A

ab at IL6 receptor

castleman’s disease
RA

red macro, t,b and neutrophil activation

35
Q

alpha4 integrin ab

A

natalizumab

rrms
crohns

36
Q

IL6 R ab

A

tocilzumab

castleman’s
RA

37
Q

anti TNF alpha

A

infliximab
adalimumab
certolizumab
golimumab

RA
ank spond
psoriasis and p. arthritis
IBD

toxicity - infection (TB, HBV, HCV), lupus-like conditions

38
Q

infliximab

A

anti TNF alpha

RA
ank spond
Psoriasis and p. arthritis
IBD

toxicity - infection (TB, HBV, HCV), lupus-like conditions

39
Q

adalimumab

A

anti TNF alpha

RA
ank spond
Psoriasis and p. arthritis
IBD

toxicity - infection (TB, HBV, HCV), lupus-like conditions

40
Q

certolizumab

A

anti TNF alpha

RA
ank spond
Psoriasis and p. arthritis
IBD

toxicity - infection (TB, HBV, HCV), lupus-like conditions

41
Q

golimumab

A

anti TNF alpha

RA
ank spond
Psoriasis and p. arthritis
IBD

toxicity - infection (TB, HBV, HCV), lupus-like conditions

42
Q

TNF alpha antagonist (fusion protein)

A

Etanercept

RA
ank spond
psoriasis and p. arthritis

NO IBD USAGE

toxicity - infection (TB, HBV, HCV), lupus-like conditions

43
Q

etanercept

A

TNF alpha antag
fusion protein

RA
ank spond
psoriasis and p. arthritis

NO IBD USAGE

toxicity - infection (TB, HBV, HCV), lupus-like conditions

44
Q

ustekinumab

A

ab to p40 subuint of
IL12 (p40+p35)
IL23 (p40+p19)

psoriasis and p arthritis

toxicity - infection TB

45
Q

ab to p40 subuint of
IL12 (p40+p35)
IL23 (p40+p19)

A

USTEKINUMAB

46
Q

denosumab

A

ab at RANK ligand

osteoporosis

toxictiy - avascular nerosis of jaw

47
Q

inihibit RANK ligand

A

denosumab

osteoporosis

48
Q

osteoporosis

A

denosumab - RANKL

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