Haem - Blood transfusions

Question 1

Haemolytic disease of the newborn

1 pathophysiology

2 sx

3 anything else of note

4 management

Answer 1

1
person form red cell Ab through blood transfusion
or fetal cells enter woman’s circulation during pregnancy/delivery (priming bit).

If mum Ab level high –> destroy fetal red cells if have red cell Ag

2
sx: fetal anaemia + jaundice

3
only IgG cross placenta
often anti D (other anti-c, anti K, IgG ABO)

4
transfuse RhD negative blood ONLY to women of childbearing age who are RhDneg