Immuno Flashcards
1
Q
Type 1 and Type 2 diabetes can be differentiated by the: Age of the pt BMI of the pt Involvement of T cells Level of fasting glucose
A
involvement of T cells
2
Q
CTLA4 (CD152) is expressed on: Activated B cells Activated T cells APCs Naïve B cells Naïve T cells
A
activated T cells
3
Q
CTLA binds to: CD4 molecules CD8 molecules CD80/86 molecules HLA class I HLA class II
A
CD80/86 molecules
4
Q
A titer of 1: 160 is ____ than a titer of 1:4000
less
greater
A
less
5
Q
Anti TPO Abs are found in: graves hashimoto both neither
A
hashimoto
6
Q
Lymphocytes that interact w/ antigen in the absence of a co-stimulatory interaction are inactivated by a process termed: Anergy Apoptosis Hyperergia Necrosis Programmed cell death
A
anergy
7
Q
Potentially self-reactive T cells are eliminated in the thymus by: AIRE selection Negative selection Positive selection T regulatory cells
A
negative selection
8
Q
Cytokines capable of inhibiting T cells IL-1 and THF alpha IL-2 and IL-4 IL-10 and TGF beta IL-12 and IFN gamma
A
Il-10 and TGF beta
9
Q
What antibodies are associated with graves?
A
TSHR and TSI
10
Q
What antibodies are associated with hashimotos
A
TPO, TG
11
Q
What thyroid disease process is associated with T cells (CD8)
A
hashimotos
12
Q
Which thyroid dz is associated with HLA DR3 and HLA B8
A
graves
13
Q
What is type 1 diabetes characterized by:
A
T cell infiltration of pancreatic islets
Presence of autoantibodies in peripheral blood
Mainly associated with HLA genes
14
Q
Type 2 characteristics
A
Inability of body cells to take up or utilize insulin
15
Q
Which genes mainly responsible for type I DM
A
IDDM on chromosome 6
